Admission Hyperglycemia in Non-diabetics Predicts Mortality and Disease Severity in COVID-19: a Pooled Analysis and Meta-summary of Literature.

COVID-19 Diabetes Hyperglycemia Infectious disease SARS-CoV-2

Journal

SN comprehensive clinical medicine
ISSN: 2523-8973
Titre abrégé: SN Compr Clin Med
Pays: Switzerland
ID NLM: 101740833

Informations de publication

Date de publication:
2020
Historique:
accepted: 04 10 2020
pubmed: 20 10 2020
medline: 20 10 2020
entrez: 19 10 2020
Statut: ppublish

Résumé

In the latter part of 2019, a cluster of unexplained pneumonia cases were reported in Wuhan, China. In less than a year, SARS-CoV-2 has infected over 27 million people and claimed more than 800,000 deaths worldwide. Diabetes is a highly prevalent chronic metabolic disease, and recent reports have suggested a possible existence of COVID-19 related new-onset diabetes. Hyperglycemia induces an inflammatory state in the body, which coupled with coronavirus associated immune response is a possible explanation for clinical worsening of patients. We present a summary and pooled analysis of available evidence to ascertain the relationship between hyperglycemia in undiagnosed diabetics and outcomes of COVID-19 disease. Our results showed that hyperglycemia in non-diabetics was associated with higher risk of severe/critical illness (OR 1.837 (95% CI 1.368-2.465,

Identifiants

pubmed: 33073173
doi: 10.1007/s42399-020-00575-8
pii: 575
pmc: PMC7550017
doi:

Types de publication

Journal Article

Langues

eng

Pagination

2161-2166

Informations de copyright

© Springer Nature Switzerland AG 2020.

Déclaration de conflit d'intérêts

Conflict of InterestThe authors declare that they have no conflict of interest.

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Auteurs

Sonali Sachdeva (S)

Department of Anesthesiology and Critical Care Medicine, Maulana Azad Medical College, New Delhi, India.

Rupak Desai (R)

Division of Cardiology, Atlanta VA Medical Center, 1670 Clairmont Rd, Decatur, GA USA.

Udita Gupta (U)

Division of General Medicine, Lady Hardinge Medical College, New Delhi, India.

Anupam Prakash (A)

Division of General Medicine, Lady Hardinge Medical College, New Delhi, India.

Abhinav Jain (A)

Department of Cardiology, Ascension Genesys Hospital, Grand Blanc, MI USA.

Ankita Aggarwal (A)

Department of Internal Medicine, Wayne State University, Detroit, MI USA.

Classifications MeSH