The tRNA-like small noncoding RNA mascRNA promotes global protein translation.
MALAT1
mascRNA
multi-tRNA synthetase complex
tRNA-like structure
translation
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
03 12 2020
03 12 2020
Historique:
received:
14
11
2019
revised:
16
09
2020
accepted:
21
09
2020
pubmed:
20
10
2020
medline:
28
4
2021
entrez:
19
10
2020
Statut:
ppublish
Résumé
mascRNA is a small cytoplasmic RNA derived from the lncRNA MALAT1. After being processed by the tRNA processing enzymes RNase P and RNase Z, mascRNA undergoes CCA addition like tRNAs and folds into a tRNA-like cloverleaf structure. While MALAT1 functions in multiple cellular processes, the role of mascRNA was largely unknown. Here, we show that mascRNA binds directly to the multi-tRNA synthetase complex (MSC) component glutaminyl-tRNA synthetase (QARS). mascRNA promotes global protein translation and cell proliferation by positively regulating QARS protein levels. Our results uncover a role of mascRNA that is independent of MALAT1, but could be part of the molecular mechanism of MALAT1's function in cancer, and provide a paradigm for understanding tRNA-like structures in mammalian cells.
Identifiants
pubmed: 33073493
doi: 10.15252/embr.201949684
pmc: PMC7726780
doi:
Substances chimiques
RNA, Long Noncoding
0
RNA, Small Untranslated
0
RNA, Transfer
9014-25-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e49684Subventions
Organisme : Ministry of Science and Technology of the People's Republic of China (MOST)
ID : 2017YFA0504600
Organisme : National Natural Science Foundation of China (NSFC)
ID : 91949103
Organisme : National Natural Science Foundation of China (NSFC)
ID : 91649103
Informations de copyright
© 2020 The Authors.
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