The microbiota-microglia axis in central nervous system disorders.
CNS diseases
bacteria
fecal microbiota transplantation
germ-free
gut-brain axis
microbiota
microbiota-microglia axis
microglia
short-chain fatty acids
Journal
Brain pathology (Zurich, Switzerland)
ISSN: 1750-3639
Titre abrégé: Brain Pathol
Pays: Switzerland
ID NLM: 9216781
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
pubmed:
20
10
2020
medline:
7
10
2021
entrez:
19
10
2020
Statut:
ppublish
Résumé
The innate immune system in the central nervous system (CNS) is mainly represented by specialized tissue-resident macrophages, called microglia. In the past years, various species-, host- and tissue-specific as well as environmental factors were recognized that essentially affect microglial properties and functions in the healthy and diseased brain. Host microbiota are mostly residing in the gut and contribute to microglial activation states, for example, via short-chain fatty acids (SCFAs) or aryl hydrocarbon receptor (AhR) ligands. Thereby, the gut microorganisms are deemed to influence numerous CNS diseases mediated by microglia. In this review, we summarize recent findings of the interaction between the host microbiota and the CNS in health and disease, where we specifically highlight the resident gut microbiota as a crucial environmental factor for microglial function as what we coin "the microbiota-microglia axis."
Identifiants
pubmed: 33073887
doi: 10.1111/bpa.12908
pmc: PMC8018151
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1159-1177Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB/TRR167
Informations de copyright
© 2020 International Society of Neuropathology.
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