The Positively Charged C-Terminal Region of Human Skeletal Troponin T Retards Activation and Decreases Calcium Sensitivity.

Calcium / pharmacology Humans Kinetics Muscle, Skeletal / drug effects Tropomyosin / chemistry Troponin C / chemistry Troponin I / chemistry Troponin T / chemistry

Journal

Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623

Informations de publication

Date de publication:
03 11 2020
Historique:
pubmed: 20 10 2020
medline: 10 4 2021
entrez: 19 10 2020
Statut: ppublish

Résumé

Calcium binding to troponin C (TnC) activates striated muscle contraction by removing TnI (troponin I) from its inhibitory site on actin. Troponin T (TnT) links TnI with tropomyosin, causing tropomyosin to move from an inhibitory position on actin to an activating position. Positive charges within the C-terminal region of human cardiac TnT limit Ca

Identifiants

DOI: 10.1021/acs.biochem.0c00499 PMID: 33074652
pubmed: 33074652
doi: 10.1021/acs.biochem.0c00499
doi:

Substances chimiques

Tropomyosin 0
Troponin C 0
Troponin I 0
Troponin T 0
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4189-4201

Auteurs

Alfredo Jesus Lopez Davila (AJ)

Institute of Molecular and Cell Physiology, Hannover Medical School, Carl-Neuberg-Street 1, 103-Block 1-Ebene 03-1010, Hannover 30625, Germany.

Li Zhu (L)

Department of Biochemistry & Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27834, United States.

Leon Fritz (L)

Institute of Molecular and Cell Physiology, Hannover Medical School, Carl-Neuberg-Street 1, 103-Block 1-Ebene 03-1010, Hannover 30625, Germany.

Theresia Kraft (T)

Institute of Molecular and Cell Physiology, Hannover Medical School, Carl-Neuberg-Street 1, 103-Block 1-Ebene 03-1010, Hannover 30625, Germany.

Joseph M Chalovich (JM)

Department of Biochemistry & Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27834, United States.
ORCID: 0000-0002-1243-4055

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › The Positively Charged C-Terminal Region of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Positively Charged C-Terminal Region of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › The Positively Charged C-Terminal Region of...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › The Positively Charged C-Terminal Region of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Tropomyosine › The Positively Charged C-Terminal Region of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Troponine › Troponine C › The Positively Charged C-Terminal Region of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Troponine › Troponine I › The Positively Charged C-Terminal Region of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Troponine › Troponine T › The Positively Charged C-Terminal Region of...