Advanced glycation end-products disrupt brain microvascular endothelial cell barrier: The role of mitochondria and oxidative stress.

Animals Brain / blood supply Capillary Permeability / drug effects Cell Line Endothelial Cells / drug effects Glycation End Products, Advanced / toxicity Mice Microvessels / drug effects Mitochondria / drug effects Oxidative Stress / drug effects Reactive Oxygen Species / metabolism Serum Albumin, Bovine / toxicity
Advanced glycation end-products Diabetes Endothelial dysfunction Mitochondria Oxidative stress

Journal

Microvascular research
ISSN: 1095-9319
Titre abrégé: Microvasc Res
Pays: United States
ID NLM: 0165035

Informations de publication

Date de publication:
01 2021
Historique:
received: 28 07 2020
revised: 06 10 2020
accepted: 14 10 2020
pubmed: 20 10 2020
medline: 18 2 2021
entrez: 19 10 2020
Statut: ppublish

Résumé

During diabetes mellitus, advanced glycation end-products (AGEs) are major contributors to the development of alterations in cerebral capillaries, leading to the disruption of the blood-brain barrier (BBB). Consequently, this is often associated with an amplified oxidative stress response in microvascular endothelial cells. As a model to mimic brain microvasculature, the bEnd.3 endothelial cell line was used to investigate cell barrier function. Cells were exposed to native bovine serum albumin (BSA) or modified BSA (BSA-AGEs). In the presence or absence of the antioxidant compound, N-acetyl-cysteine, cell permeability was assessed by FITC-dextran exclusion, intracellular free radical formation was monitored with H

Identifiants

DOI: 10.1016/j.mvr.2020.104098 PMID: 33075405 PMC: PMC8782206
pubmed: 33075405
pii: S0026-2862(20)30158-8
doi: 10.1016/j.mvr.2020.104098
pmc: PMC8782206
mid: NIHMS1657071
pii:
doi:

Substances chimiques

Glycation End Products, Advanced 0
Reactive Oxygen Species 0
advanced glycation end products-bovine serum albumin 0
Serum Albumin, Bovine 27432CM55Q

Types de publication

Journal Article Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

104098

Subventions

Organisme : Intramural NIH HHS
ID : Z01 ES021164
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

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Auteurs

Anthony Dobi (A)

Inserm, UMR 1188 Diabète Athérothrombose Thérapies Réunion Océan Indien (DéTROI), plateforme CYROI, 97490 Sainte-Clotilde, France; Université de La Réunion, UMR 1188, 97490 Sainte-Clotilde, France.

Sarah Rosanaly (S)

Inserm, UMR 1188 Diabète Athérothrombose Thérapies Réunion Océan Indien (DéTROI), plateforme CYROI, 97490 Sainte-Clotilde, France; Université de La Réunion, UMR 1188, 97490 Sainte-Clotilde, France.

Anne Devin (A)

CNRS, Institut de Biochimie et Génétique Cellulaires, UMR 5095, Université de Bordeaux, F-33000 Bordeaux, France.

Pascal Baret (P)

Inserm, UMR 1188 Diabète Athérothrombose Thérapies Réunion Océan Indien (DéTROI), plateforme CYROI, 97490 Sainte-Clotilde, France; Université de La Réunion, UMR 1188, 97490 Sainte-Clotilde, France.

Olivier Meilhac (O)

Inserm, UMR 1188 Diabète Athérothrombose Thérapies Réunion Océan Indien (DéTROI), plateforme CYROI, 97490 Sainte-Clotilde, France; Université de La Réunion, UMR 1188, 97490 Sainte-Clotilde, France; CHU de La Réunion, Centre d'Investigation Clinique, 97400 Saint-Denis, France.

G Jean Harry (GJ)

Neurotoxicology Group, National Toxicology Program Laboratory, National Institute of Environmental Health Sciences, 27709 Research Triangle Park, NC, USA.

Christian Lefebvre d'Hellencourt (CL)

Inserm, UMR 1188 Diabète Athérothrombose Thérapies Réunion Océan Indien (DéTROI), plateforme CYROI, 97490 Sainte-Clotilde, France; Université de La Réunion, UMR 1188, 97490 Sainte-Clotilde, France; Neurotoxicology Group, National Toxicology Program Laboratory, National Institute of Environmental Health Sciences, 27709 Research Triangle Park, NC, USA. Electronic address: christian.lefebvre-d-hellencourt@univ-reunion.fr.

Philippe Rondeau (P)

Inserm, UMR 1188 Diabète Athérothrombose Thérapies Réunion Océan Indien (DéTROI), plateforme CYROI, 97490 Sainte-Clotilde, France; Université de La Réunion, UMR 1188, 97490 Sainte-Clotilde, France. Electronic address: rophil@univ-reunion.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Advanced glycation end-products disrupt brain...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Advanced glycation end-products disrupt brain...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Perméabilité capillaire › Advanced glycation end-products disrupt brain...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Advanced glycation end-products disrupt brain...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Advanced glycation end-products disrupt brain...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Produits terminaux de glycation avancée › Advanced glycation end-products disrupt brain...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Advanced glycation end-products disrupt brain...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Microvaisseaux › Advanced glycation end-products disrupt brain...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Advanced glycation end-products disrupt brain...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Advanced glycation end-products disrupt brain...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Advanced glycation end-products disrupt brain...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Sérumalbumine › Sérumalbumine bovine › Advanced glycation end-products disrupt brain...