Methylene blue inhibits replication of SARS-CoV-2 in vitro.

Animals Chlorocebus aethiops Methylene Blue / pharmacology SARS-CoV-2 / drug effects Vero Cells Virus Replication / drug effects COVID-19 Drug Treatment
Antiviral COVID-19 Coronavirus In vitro Methylene blue SARS-CoV-2

Journal

International journal of antimicrobial agents
ISSN: 1872-7913
Titre abrégé: Int J Antimicrob Agents
Pays: Netherlands
ID NLM: 9111860

Informations de publication

Date de publication:
Dec 2020
Historique:
received: 07 05 2020
revised: 07 10 2020
accepted: 11 10 2020
pubmed: 20 10 2020
medline: 15 12 2020
entrez: 19 10 2020
Statut: ppublish

Résumé

In December 2019, a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus diseases 2019 (COVID-19) emerged in Wuhan, China. Currently there is no antiviral treatment recommended against SARS-CoV-2. Identifying effective antiviral drugs is urgently required. Methylene blue has already demonstrated in vitro antiviral activity in photodynamic therapy as well as antibacterial, antifungal and antiparasitic activities in non-photodynamic assays. In this study. non-photoactivated methylene blue showed in vitro activity at very low micromolar range with an EC

Identifiants

DOI: 10.1016/j.ijantimicag.2020.106202 PMID: 33075512 PMC: PMC7566888
pubmed: 33075512
pii: S0924-8579(20)30408-8
doi: 10.1016/j.ijantimicag.2020.106202
pmc: PMC7566888
pii:
doi:

Substances chimiques

Methylene Blue T42P99266K

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106202

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

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Auteurs

Mathieu Gendrot (M)

Unité Parasitologie et Entomologie, Département Microbiologie et Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France; Aix-Marseille Université, IRD, SSA, AP-HM, VITROME, Marseille, France; IHU Méditerranée Infection, Marseille, France.

Julien Andreani (J)

IHU Méditerranée Infection, Marseille, France; Aix-Marseille Université, IRD, AP-HM, MEPHI, Marseille, France.

Isabelle Duflot (I)

IHU Méditerranée Infection, Marseille, France; Aix-Marseille Université, IRD, AP-HM, MEPHI, Marseille, France.

Manon Boxberger (M)

IHU Méditerranée Infection, Marseille, France; Aix-Marseille Université, IRD, AP-HM, MEPHI, Marseille, France.

Marion Le Bideau (M)

IHU Méditerranée Infection, Marseille, France; Aix-Marseille Université, IRD, AP-HM, MEPHI, Marseille, France.

Joel Mosnier (J)

Unité Parasitologie et Entomologie, Département Microbiologie et Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France; Aix-Marseille Université, IRD, SSA, AP-HM, VITROME, Marseille, France; IHU Méditerranée Infection, Marseille, France; Centre National de Référence du Paludisme, Marseille, France.

Priscilla Jardot (P)

IHU Méditerranée Infection, Marseille, France; Aix-Marseille Université, IRD, AP-HM, MEPHI, Marseille, France.

Isabelle Fonta (I)

Unité Parasitologie et Entomologie, Département Microbiologie et Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France; Aix-Marseille Université, IRD, SSA, AP-HM, VITROME, Marseille, France; IHU Méditerranée Infection, Marseille, France; Centre National de Référence du Paludisme, Marseille, France.

Clara Rolland (C)

IHU Méditerranée Infection, Marseille, France; Aix-Marseille Université, IRD, AP-HM, MEPHI, Marseille, France.

Hervé Bogreau (H)

Unité Parasitologie et Entomologie, Département Microbiologie et Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France; Aix-Marseille Université, IRD, SSA, AP-HM, VITROME, Marseille, France; IHU Méditerranée Infection, Marseille, France; Centre National de Référence du Paludisme, Marseille, France.

Sébastien Hutter (S)

IHU Méditerranée Infection, Marseille, France; Aix-Marseille Université, IRD, AP-HM, MEPHI, Marseille, France.

Bernard La Scola (B)

IHU Méditerranée Infection, Marseille, France; Aix-Marseille Université, IRD, AP-HM, MEPHI, Marseille, France. Electronic address: bernard.la-scola@univ-amu.fr.

Bruno Pradines (B)

Unité Parasitologie et Entomologie, Département Microbiologie et Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France; IHU Méditerranée Infection, Marseille, France; Aix-Marseille Université, IRD, SSA, AP-HM, VITROME, Marseille, France; Centre National de Référence du Paludisme, Marseille, France. Electronic address: bruno.pradines@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Methylene blue inhibits replication of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercopithecus › Cercopithecus aethiops › Methylene blue inhibits replication of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Phénothiazines › Bleu de méthylène › Methylene blue inhibits replication of...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Methylene blue inhibits replication of...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Vero › Methylene blue inhibits replication of...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Methylene blue inhibits replication of...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Traitements médicamenteux de la COVID-19 › Methylene blue inhibits replication of...