Circulating MiRNA-195-5p and -451a in Diabetic Patients with Transient and Acute Ischemic Stroke in the Emergency Department.
acute ischemic stroke
diabetes mellitus
emergency
microRNA
transient ischemic attack
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Oct 2020
15 Oct 2020
Historique:
received:
28
09
2020
revised:
07
10
2020
accepted:
13
10
2020
entrez:
20
10
2020
pubmed:
21
10
2020
medline:
26
2
2021
Statut:
epublish
Résumé
(1) Background: Circulating micro-RNAs (miRNAs) modulate the expression of molecules in diabetes. We evaluated the expression of serum miRNA-195-5p and -451a in diabetic patients with ischemic stroke and correlated them with two markers of brain tissue integrity. (2) Methods: Seventy-eight subjects with acute ischemic stroke (AIS) or transient ischemic attack (TIA) (40 with diabetes) were enrolled. Serum miRNA levels, brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor A (VEGF-A) were assessed at admission and 24 and 72 h after a post-ischemic stroke, and were compared to 20 controls. (3) Results: Both circulating miRNAs were two-fold up-regulated in diabetic AIS and TIA patients compared to non-diabetics. Their levels progressively decreased at 24 and 72 h in both AIS and TIA patients. Interestingly, in the non-diabetic TIA group, both circulating miRNAs, although higher than the controls, tended to achieve a complete decay after 72 h. Furthermore, miRNA-195-5p and miRNA-451a levels inversely correlated with both BDNF and VEGF-A serum levels. (4) Conclusions: These data show a different profile of both micro-RNAs in diabetic versus non-diabetic patients after acute ischemic stroke, suggesting their pivotal role in cerebrovascular ischemic attack.
Identifiants
pubmed: 33076256
pii: ijms21207615
doi: 10.3390/ijms21207615
pmc: PMC7593949
pii:
doi:
Substances chimiques
Biomarkers
0
Brain-Derived Neurotrophic Factor
0
MIRN195 microRNA, human
0
MIRN451 microRNA, human
0
MicroRNAs
0
Vascular Endothelial Growth Factor A
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Int Angiol. 2006 Sep;25(3):261-7
pubmed: 16878074
J Neuroinflammation. 2019 Apr 17;16(1):88
pubmed: 30995924
Oncol Rep. 2016 Sep;36(3):1385-92
pubmed: 27461244
Cells. 2018 Dec 06;7(12):
pubmed: 30563269
Curr Opin Investig Drugs. 2010 Mar;11(3):298-308
pubmed: 20178043
J Clin Med. 2016 Jun 06;5(6):
pubmed: 27275837
J Clin Med. 2019 Jan 22;8(2):
pubmed: 30678250
Stroke. 2012 Aug;43(8):2270-4
pubmed: 22618382
J Exp Neurosci. 2019 Mar 08;13:1179069519832286
pubmed: 30886525
J Clin Invest. 2013 Mar;123(3):1057-67
pubmed: 23426184
Clin Biochem Rev. 2009 Nov;30(4):197-200
pubmed: 20011212
Curr Vasc Pharmacol. 2015;13(3):352-65
pubmed: 26156265
Stroke. 2019 Dec;50(12):e344-e418
pubmed: 31662037
Eur J Heart Fail. 2013 Nov;15(11):1277-88
pubmed: 23736534
Prog Neurobiol. 2014 Apr;115:138-56
pubmed: 24291532
Am J Med Sci. 2016 Apr;351(4):380-6
pubmed: 27079344
Stroke. 2009 Jun;40(6):2276-93
pubmed: 19423857
Int J Clin Pract. 2013 Dec;67(12):1247-53
pubmed: 24246205
World J Orthop. 2015 Jan 18;6(1):62-76
pubmed: 25621212
J Neuroinflammation. 2017 Jan 23;14(1):21
pubmed: 28115020
Mol Med Rep. 2017 Oct;16(4):5434-5440
pubmed: 28849133