Nonhistone Proteins HMGB1 and HMGB2 Differentially Modulate the Response of Human Embryonic Stem Cells and the Progenitor Cells to the Anticancer Drug Etoposide.
Antineoplastic Agents
/ pharmacology
Apoptosis
/ drug effects
Cell Differentiation
/ genetics
Etoposide
/ pharmacology
Gene Expression Regulation, Neoplastic
/ genetics
HMGB1 Protein
/ antagonists & inhibitors
HMGB2 Protein
/ antagonists & inhibitors
Human Embryonic Stem Cells
Humans
Neoplasms
/ drug therapy
Neoplastic Stem Cells
/ drug effects
RNA, Small Interfering
Stem Cells
/ drug effects
Telomerase
/ genetics
HMGB1 and HMGB2
apoptosis
etoposide
human embryonic stem cells
neuroectodermal cells
telomerase
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
15 10 2020
15 10 2020
Historique:
received:
14
09
2020
revised:
09
10
2020
accepted:
09
10
2020
entrez:
20
10
2020
pubmed:
21
10
2020
medline:
24
6
2021
Statut:
epublish
Résumé
HMGB1 and HMGB2 proteins are abundantly expressed in human embryonic stem cells (hESCs) and hESC-derived progenitor cells (neuroectodermal cells, hNECs), though their functional roles in pluripotency and the mechanisms underlying their differentiation in response to the anticancer drug etoposide remain to be elucidated. Here, we show that
Identifiants
pubmed: 33076532
pii: biom10101450
doi: 10.3390/biom10101450
pmc: PMC7602880
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
HMGB1 Protein
0
HMGB1 protein, human
0
HMGB2 Protein
0
RNA, Small Interfering
0
Etoposide
6PLQ3CP4P3
Telomerase
EC 2.7.7.49
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Health and Education of the Czech Republic
ID : NU20-08-00106
Pays : International
Organisme : Grant Agency of the Czech Republic
ID : P305-15-01354S
Pays : International
Organisme : Internal Research Support Program of the Institute of Biophysics Brno
ID : IBP CAS 68081707
Pays : International
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