Uncharacterized RNAs in Plasma of Alzheimer's Patients Are Associated with Cognitive Impairment and Show a Potential Diagnostic Power.
AD
biomarkers
lncRNAs
non-coding RNAs
non-invasive diagnosis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Oct 2020
15 Oct 2020
Historique:
received:
24
09
2020
revised:
12
10
2020
accepted:
13
10
2020
entrez:
20
10
2020
pubmed:
21
10
2020
medline:
26
2
2021
Statut:
epublish
Résumé
Alzheimer's disease (AD) diagnosis is actually based on clinical evaluation and brain-imaging tests, and it can often be confirmed only post-mortem. Therefore, new non-invasive molecular biomarkers are necessary to improve AD diagnosis. As circulating microRNA biomarkers have been proposed for many diseases, including AD, we aimed to identify new diagnostic non-small RNAs in AD. Whole transcriptome analysis was performed on plasma samples of five AD and five unaffected individuals (CTRL) using the Clariom D Pico Assay, followed by validation in real-time PCR on 37 AD patients and 37 CTRL. Six differentially expressed (DE) transcripts were identified: GS1-304P7.3 (upregulated), NONHSAT090268, TC0100011037, TC0400008478, TC1400008125, and
Identifiants
pubmed: 33076555
pii: ijms21207644
doi: 10.3390/ijms21207644
pmc: PMC7588983
pii:
doi:
Substances chimiques
Biomarkers
0
Cell-Free Nucleic Acids
0
RNA, Untranslated
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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