Is meconium exposure associated with autism spectrum disorders in children?
Autism spectrum disorder
Meconium
Meta-analysis
Journal
Clinical and experimental pediatrics
ISSN: 2713-4148
Titre abrégé: Clin Exp Pediatr
Pays: Korea (South)
ID NLM: 101761234
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
15
06
2020
accepted:
12
08
2020
pubmed:
21
10
2020
medline:
21
10
2020
entrez:
20
10
2020
Statut:
ppublish
Résumé
The results differ among published studies regarding exposure to meconium and the risk of developing autism spectrum disorders (ASDs). The present study pooled all of the epidemiologic studies retrieved from broader databases on the association between meconium exposure and risk of developing ASD in children. The Web of Science, PubMed, Scopus, and Google Scholar databases were searched without language restrictions for articles published between their inception to February 20, 2020, using relevant keywords. The pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated as random-effect estimates of the associations among studies. A subgroup analysis was conducted to explore any potential sources of heterogeneity among studies. The pooled estimate of OR reported a weakly significant association between meconium exposure and ASD development in children (OR, 1.13; 95% CI, 1.03-1.24). There was low heterogeneity among the articles reporting risk for ASD among children (I2=19.3%; P=0.259). The results of subgroup analysis based on meconium exposure showed a significant association between a meconium-stained neonate and ASD development (OR, 1.18; 95% CI, 1.11-1.24). Meconium exposure was weakly associated with an increased risk of ASD. However, more evidence based on large prospective cohort studies is required to provide conclusive evidence about whether meconium exposure is associated with an increased risk of ASD development.
Sections du résumé
BACKGROUND
BACKGROUND
The results differ among published studies regarding exposure to meconium and the risk of developing autism spectrum disorders (ASDs).
PURPOSE
OBJECTIVE
The present study pooled all of the epidemiologic studies retrieved from broader databases on the association between meconium exposure and risk of developing ASD in children.
METHODS
METHODS
The Web of Science, PubMed, Scopus, and Google Scholar databases were searched without language restrictions for articles published between their inception to February 20, 2020, using relevant keywords. The pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated as random-effect estimates of the associations among studies. A subgroup analysis was conducted to explore any potential sources of heterogeneity among studies.
RESULTS
RESULTS
The pooled estimate of OR reported a weakly significant association between meconium exposure and ASD development in children (OR, 1.13; 95% CI, 1.03-1.24). There was low heterogeneity among the articles reporting risk for ASD among children (I2=19.3%; P=0.259). The results of subgroup analysis based on meconium exposure showed a significant association between a meconium-stained neonate and ASD development (OR, 1.18; 95% CI, 1.11-1.24).
CONCLUSION
CONCLUSIONS
Meconium exposure was weakly associated with an increased risk of ASD. However, more evidence based on large prospective cohort studies is required to provide conclusive evidence about whether meconium exposure is associated with an increased risk of ASD development.
Identifiants
pubmed: 33076638
pii: cep.2020.01053
doi: 10.3345/cep.2020.01053
pmc: PMC8255516
doi:
Types de publication
Journal Article
Langues
eng
Pagination
341-346Subventions
Organisme : Hamadan University of Medical Sciences
Commentaires et corrections
Type : CommentIn
Références
J Bone Miner Res. 2018 Mar;33(3):458-466
pubmed: 29178513
J Neurosci. 2012 Jun 27;32(26):8930-9
pubmed: 22745493
Pediatr Neurol. 2014 Dec;51(6):776-80
pubmed: 25303867
Pediatrics. 2012 May;129(5):e1121-8
pubmed: 22492772
Early Hum Dev. 2014 Jul;90(7):333-9
pubmed: 24794305
J Am Acad Child Adolesc Psychiatry. 1993 Nov;32(6):1256-63
pubmed: 8282673
JAMA Pediatr. 2013 Oct;167(10):959-66
pubmed: 23938610
J Autism Dev Disord. 1999 Apr;29(2):161-6
pubmed: 10382137
JAMA Pediatr. 2015 Feb;169(2):154-62
pubmed: 25485869
Eur J Neurol. 2017 Aug;24(8):1006-1015
pubmed: 28646492
Int J Pediatr. 2012;2012:965159
pubmed: 22518190
BMJ. 2013 Apr 19;346:f2059
pubmed: 23604083
Semin Fetal Neonatal Med. 2007 Oct;12(5):398-407
pubmed: 17825633
Curr Opin Obstet Gynecol. 2019 Dec;31(6):410-417
pubmed: 31567446
Pediatrics. 2009 May;123(5):1293-300
pubmed: 19403494
Early Hum Dev. 2014 Jul;90(7):325-8
pubmed: 24794302
J Perinatol. 2008 Dec;28 Suppl 3:S93-101
pubmed: 19057618
Pediatr Res. 2009 Jun;65(6):591-8
pubmed: 19218885
J Perinatol. 2017 Feb;37(2):203-207
pubmed: 27809298
Dialogues Clin Neurosci. 2012 Sep;14(3):281-92
pubmed: 23226953
J Perinatol. 2008 Dec;28 Suppl 3:S3-7
pubmed: 19057607
Pediatrics. 2014 May;133(5):e1241-8
pubmed: 24733881
J Indian Med Assoc. 2012 Aug;110(8):526-9
pubmed: 23741815
Acta Psychiatr Scand. 2006 Oct;114(4):257-64
pubmed: 16968363
Am J Obstet Gynecol. 2012 Apr;206(4):314.e1-9
pubmed: 22464070
Pediatrics. 2011 Aug;128(2):344-55
pubmed: 21746727