Imaging Cardiovascular and Lung Macrophages With the Positron Emission Tomography Sensor

Animals Atherosclerosis / diagnostic imaging Copper Radioisotopes / administration & dosage Dextrans / administration & dosage Disease Models, Animal Heart / diagnostic imaging Injections, Intravenous Lung / diagnostic imaging Macrophages / pathology Macrophages, Alveolar / pathology Mice Molecular Imaging Myocardial Infarction / diagnostic imaging Nanoparticles Pneumonia / diagnostic imaging Positron Emission Tomography Computed Tomography Predictive Value of Tests Rabbits Radiopharmaceuticals / administration & dosage Swine Swine, Miniature Time Factors
heart macrophages myocardial infarction nanoparticles pneumonia

Journal

Circulation. Cardiovascular imaging
ISSN: 1942-0080
Titre abrégé: Circ Cardiovasc Imaging
Pays: United States
ID NLM: 101479935

Informations de publication

Date de publication:
10 2020
Historique:
entrez: 20 10 2020
pubmed: 21 10 2020
medline: 16 3 2021
Statut: ppublish

Résumé

Macrophages, innate immune cells that reside in all organs, defend the host against infection and injury. In the heart and vasculature, inflammatory macrophages also enhance tissue damage and propel cardiovascular diseases. We here use in vivo positron emission tomography (PET) imaging, flow cytometry, and confocal microscopy to evaluate quantitative noninvasive assessment of cardiac, arterial, and pulmonary macrophages using the nanotracer PET imaging using Taken together, these results indicate

Sections du résumé

BACKGROUND
Macrophages, innate immune cells that reside in all organs, defend the host against infection and injury. In the heart and vasculature, inflammatory macrophages also enhance tissue damage and propel cardiovascular diseases.
METHODS
We here use in vivo positron emission tomography (PET) imaging, flow cytometry, and confocal microscopy to evaluate quantitative noninvasive assessment of cardiac, arterial, and pulmonary macrophages using the nanotracer
RESULTS
PET imaging using
CONCLUSIONS
Taken together, these results indicate

Identifiants

DOI: 10.1161/CIRCIMAGING.120.010586 PMID: 33076700 PMC: PMC7583675
pubmed: 33076700
doi: 10.1161/CIRCIMAGING.120.010586
pmc: PMC7583675
mid: NIHMS1632097
doi:

Substances chimiques

Copper Radioisotopes 0
Copper-64 0
Dextrans 0
Radiopharmaceuticals 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e010586

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL144072
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL125428
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL131478
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL131495
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL139598
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA220234
Pays : United States

Commentaires et corrections

Type : CommentIn

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Auteurs

Matthias Nahrendorf (M)

Center for Systems Biology (M.N., F.F.H., D.R., A.D.A., G.W., S.S., Y.I., F.K.S., R.W.), Massachusetts General Hospital Research Institute and Harvard Medical School, Boston.
Department of Radiology (M.N., F.F.H., D.R., F.K.S., R.W.), Massachusetts General Hospital Research Institute and Harvard Medical School, Boston.
Cardiovascular Research Center (M.N., A.D.A.), Massachusetts General Hospital Research Institute and Harvard Medical School, Boston.
Department of Internal Medicine I, University Hospital Wuerzburg, Germany (M.N.).

Friedrich Felix Hoyer (FF)

Center for Systems Biology (M.N., F.F.H., D.R., A.D.A., G.W., S.S., Y.I., F.K.S., R.W.), Massachusetts General Hospital Research Institute and Harvard Medical School, Boston.
Department of Radiology (M.N., F.F.H., D.R., F.K.S., R.W.), Massachusetts General Hospital Research Institute and Harvard Medical School, Boston.

Anu E Meerwaldt (AE)

Biomedical Engineering and Imaging Institute (A.E.M., M.M.T.v.L., M.L.S., C.C., P.M.R., G.S., C.P.-M., A.J.P.T., Y.C.T., K.S., E.M.v.L., E.D.K., A.M.S., W.J.M.M.), Icahn School of Medicine at Mount Sinai, New York, NY.
Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht and Utrecht University, the Netherlands (A.E.M., E.M.v.L.).

Mandy M T van Leent (MMT)

Biomedical Engineering and Imaging Institute (A.E.M., M.M.T.v.L., M.L.S., C.C., P.M.R., G.S., C.P.-M., A.J.P.T., Y.C.T., K.S., E.M.v.L., E.D.K., A.M.S., W.J.M.M.), Icahn School of Medicine at Mount Sinai, New York, NY.
Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands (M.M.T.v.L., M.L.S., W.J.M.M.).

Max L Senders (ML)

Biomedical Engineering and Imaging Institute (A.E.M., M.M.T.v.L., M.L.S., C.C., P.M.R., G.S., C.P.-M., A.J.P.T., Y.C.T., K.S., E.M.v.L., E.D.K., A.M.S., W.J.M.M.), Icahn School of Medicine at Mount Sinai, New York, NY.
Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands (M.M.T.v.L., M.L.S., W.J.M.M.).

Claudia Calcagno (C)

Biomedical Engineering and Imaging Institute (A.E.M., M.M.T.v.L., M.L.S., C.C., P.M.R., G.S., C.P.-M., A.J.P.T., Y.C.T., K.S., E.M.v.L., E.D.K., A.M.S., W.J.M.M.), Icahn School of Medicine at Mount Sinai, New York, NY.

Philip M Robson (PM)

Biomedical Engineering and Imaging Institute (A.E.M., M.M.T.v.L., M.L.S., C.C., P.M.R., G.S., C.P.-M., A.J.P.T., Y.C.T., K.S., E.M.v.L., E.D.K., A.M.S., W.J.M.M.), Icahn School of Medicine at Mount Sinai, New York, NY.

George Soultanidis (G)

Biomedical Engineering and Imaging Institute (A.E.M., M.M.T.v.L., M.L.S., C.C., P.M.R., G.S., C.P.-M., A.J.P.T., Y.C.T., K.S., E.M.v.L., E.D.K., A.M.S., W.J.M.M.), Icahn School of Medicine at Mount Sinai, New York, NY.

Carlos Pérez-Medina (C)

Biomedical Engineering and Imaging Institute (A.E.M., M.M.T.v.L., M.L.S., C.C., P.M.R., G.S., C.P.-M., A.J.P.T., Y.C.T., K.S., E.M.v.L., E.D.K., A.M.S., W.J.M.M.), Icahn School of Medicine at Mount Sinai, New York, NY.
Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain (C.P.-M.).

Abraham J P Teunissen (AJP)

Biomedical Engineering and Imaging Institute (A.E.M., M.M.T.v.L., M.L.S., C.C., P.M.R., G.S., C.P.-M., A.J.P.T., Y.C.T., K.S., E.M.v.L., E.D.K., A.M.S., W.J.M.M.), Icahn School of Medicine at Mount Sinai, New York, NY.

Yohana C Toner (YC)

Biomedical Engineering and Imaging Institute (A.E.M., M.M.T.v.L., M.L.S., C.C., P.M.R., G.S., C.P.-M., A.J.P.T., Y.C.T., K.S., E.M.v.L., E.D.K., A.M.S., W.J.M.M.), Icahn School of Medicine at Mount Sinai, New York, NY.

Kiyotake Ishikawa (K)

Department of Cardiology, Cardiovascular Research Center (K.I., K.F.), Icahn School of Medicine at Mount Sinai, New York, NY.

Kenneth Fish (K)

Department of Cardiology, Cardiovascular Research Center (K.I., K.F.), Icahn School of Medicine at Mount Sinai, New York, NY.

Ken Sakurai (K)

Biomedical Engineering and Imaging Institute (A.E.M., M.M.T.v.L., M.L.S., C.C., P.M.R., G.S., C.P.-M., A.J.P.T., Y.C.T., K.S., E.M.v.L., E.D.K., A.M.S., W.J.M.M.), Icahn School of Medicine at Mount Sinai, New York, NY.

Esther M van Leeuwen (EM)

Biomedical Engineering and Imaging Institute (A.E.M., M.M.T.v.L., M.L.S., C.C., P.M.R., G.S., C.P.-M., A.J.P.T., Y.C.T., K.S., E.M.v.L., E.D.K., A.M.S., W.J.M.M.), Icahn School of Medicine at Mount Sinai, New York, NY.
Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht and Utrecht University, the Netherlands (A.E.M., E.M.v.L.).

Emma D Klein (ED)

Biomedical Engineering and Imaging Institute (A.E.M., M.M.T.v.L., M.L.S., C.C., P.M.R., G.S., C.P.-M., A.J.P.T., Y.C.T., K.S., E.M.v.L., E.D.K., A.M.S., W.J.M.M.), Icahn School of Medicine at Mount Sinai, New York, NY.

Alexandros Marios Sofias (AM)

Biomedical Engineering and Imaging Institute (A.E.M., M.M.T.v.L., M.L.S., C.C., P.M.R., G.S., C.P.-M., A.J.P.T., Y.C.T., K.S., E.M.v.L., E.D.K., A.M.S., W.J.M.M.), Icahn School of Medicine at Mount Sinai, New York, NY.
Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway (A.M.S.).

Thomas Reiner (T)

Department of Radiology and Chemical Biology Program, Memorial Sloan- Kettering Cancer Center, New York, NY (T.R.).
Department of Radiology, Weill Cornell Medical College, New York, NY (T.R.).

David Rohde (D)

Center for Systems Biology (M.N., F.F.H., D.R., A.D.A., G.W., S.S., Y.I., F.K.S., R.W.), Massachusetts General Hospital Research Institute and Harvard Medical School, Boston.
Department of Radiology (M.N., F.F.H., D.R., F.K.S., R.W.), Massachusetts General Hospital Research Institute and Harvard Medical School, Boston.

Aaron D Aguirre (AD)

Center for Systems Biology (M.N., F.F.H., D.R., A.D.A., G.W., S.S., Y.I., F.K.S., R.W.), Massachusetts General Hospital Research Institute and Harvard Medical School, Boston.
Cardiovascular Research Center (M.N., A.D.A.), Massachusetts General Hospital Research Institute and Harvard Medical School, Boston.
Wellman Center for Photomedicine (A.D.A.), Massachusetts General Hospital Research Institute and Harvard Medical School, Boston.

Gregory Wojtkiewicz (G)

Center for Systems Biology (M.N., F.F.H., D.R., A.D.A., G.W., S.S., Y.I., F.K.S., R.W.), Massachusetts General Hospital Research Institute and Harvard Medical School, Boston.

Stephen Schmidt (S)

Center for Systems Biology (M.N., F.F.H., D.R., A.D.A., G.W., S.S., Y.I., F.K.S., R.W.), Massachusetts General Hospital Research Institute and Harvard Medical School, Boston.

Yoshiko Iwamoto (Y)

Center for Systems Biology (M.N., F.F.H., D.R., A.D.A., G.W., S.S., Y.I., F.K.S., R.W.), Massachusetts General Hospital Research Institute and Harvard Medical School, Boston.

David Izquierdo-Garcia (D)

Institute for Innovation in Imaging, A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown (D.I.-G., P.C., R.W.).

Peter Caravan (P)

Institute for Innovation in Imaging, A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown (D.I.-G., P.C., R.W.).

Filip K Swirski (FK)

Center for Systems Biology (M.N., F.F.H., D.R., A.D.A., G.W., S.S., Y.I., F.K.S., R.W.), Massachusetts General Hospital Research Institute and Harvard Medical School, Boston.
Department of Radiology (M.N., F.F.H., D.R., F.K.S., R.W.), Massachusetts General Hospital Research Institute and Harvard Medical School, Boston.

Ralph Weissleder (R)

Center for Systems Biology (M.N., F.F.H., D.R., A.D.A., G.W., S.S., Y.I., F.K.S., R.W.), Massachusetts General Hospital Research Institute and Harvard Medical School, Boston.
Department of Radiology (M.N., F.F.H., D.R., F.K.S., R.W.), Massachusetts General Hospital Research Institute and Harvard Medical School, Boston.
Institute for Innovation in Imaging, A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown (D.I.-G., P.C., R.W.).
Department of Systems Biology, Harvard Medical School, Boston, MA (R.W.).

Willem J M Mulder (WJM)

Biomedical Engineering and Imaging Institute (A.E.M., M.M.T.v.L., M.L.S., C.C., P.M.R., G.S., C.P.-M., A.J.P.T., Y.C.T., K.S., E.M.v.L., E.D.K., A.M.S., W.J.M.M.), Icahn School of Medicine at Mount Sinai, New York, NY.
Department of Oncological Sciences (W.J.M.M.), Icahn School of Medicine at Mount Sinai, New York, NY.
Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands (M.M.T.v.L., M.L.S., W.J.M.M.).
Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, the Netherlands (W.J.M.M.).

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du cuivre › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Glucides › Polyosides › Glucanes › Dextrane › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Système cardiovasculaire › Coeur › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Injections › Injections veineuses › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Appareil respiratoire › Poumon › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Macrophages alvéolaires › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Imagerie moléculaire › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Tomographie par émission de positons couplée à la tomodensitométrie › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Valeur prédictive des tests › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Lagomorpha › Lapins › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Sus scrofa › Porc miniature › Imaging Cardiovascular and Lung Macrophages...
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › Imaging Cardiovascular and Lung Macrophages...