Environmental assessment of cytotoxic drugs in healthcare settings: protocol for a systematic review and meta-analysis.
Cytotoxic drugs
Environmental assessment
Meta-analysis
Systematic review
Journal
Systematic reviews
ISSN: 2046-4053
Titre abrégé: Syst Rev
Pays: England
ID NLM: 101580575
Informations de publication
Date de publication:
19 10 2020
19 10 2020
Historique:
received:
14
05
2020
accepted:
23
09
2020
entrez:
20
10
2020
pubmed:
21
10
2020
medline:
25
6
2021
Statut:
epublish
Résumé
Occupational exposure to cytotoxic drugs is associated with various unfavorable health outcomes. This protocol reports a methodology for a systematic review and meta-analysis that aims to systematically review the published literature and quantify the level of environmental contamination of healthcare settings with cytotoxic drugs. This protocol is developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol-2015 (PRISMA-P) guidelines. Six electronic databases (PubMed, Web of Science, Scopus, Cochrane Library, CINAHL, and EMBASE) will be searched with no restrictions on publication period. Eligible studies will be identified and data will be extracted using a predefined data extraction form by at least two independent reviewers following best practice. Eligible studies should report calculated or calculable estimates on the proportion of positive samples tested for cytotoxic drugs and/or estimates on the concentration of the cytotoxic drug(s) in the tested samples. Risk of bias (RoB) will be assessed by using the RoB in Studies estimating Prevalence of Exposure to Occupational risk factors (RoB-SPEO) tool, which developed by the World Health Organization (WHO) and International Labour Organization (ILO) for environmental and occupational health systematic reviews. The random-effects model will be used to perform meta-analyses. Occupational exposure to cytotoxic drugs is associated with short- and long-term adverse health outcomes. Following this protocol, the review to be carried out will be the first to fill an evidence gap on the environmental contamination of healthcare settings with cytotoxic drugs. The findings of this review will help in the understanding of the risk of occupational exposure of healthcare workers to cytotoxic drugs and facilitate the identification of priority areas for specific interventions. The systematic review methodology does not require ethics approval due to the nature of the study design. The results of the systematic review will be published in a peer-reviewed journal and will be publicly available. PROSPERO CRD42020162780 , dated July 14, 2020.
Sections du résumé
BACKGROUND
Occupational exposure to cytotoxic drugs is associated with various unfavorable health outcomes. This protocol reports a methodology for a systematic review and meta-analysis that aims to systematically review the published literature and quantify the level of environmental contamination of healthcare settings with cytotoxic drugs.
METHODS
This protocol is developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol-2015 (PRISMA-P) guidelines. Six electronic databases (PubMed, Web of Science, Scopus, Cochrane Library, CINAHL, and EMBASE) will be searched with no restrictions on publication period. Eligible studies will be identified and data will be extracted using a predefined data extraction form by at least two independent reviewers following best practice. Eligible studies should report calculated or calculable estimates on the proportion of positive samples tested for cytotoxic drugs and/or estimates on the concentration of the cytotoxic drug(s) in the tested samples. Risk of bias (RoB) will be assessed by using the RoB in Studies estimating Prevalence of Exposure to Occupational risk factors (RoB-SPEO) tool, which developed by the World Health Organization (WHO) and International Labour Organization (ILO) for environmental and occupational health systematic reviews. The random-effects model will be used to perform meta-analyses.
DISCUSSION
Occupational exposure to cytotoxic drugs is associated with short- and long-term adverse health outcomes. Following this protocol, the review to be carried out will be the first to fill an evidence gap on the environmental contamination of healthcare settings with cytotoxic drugs. The findings of this review will help in the understanding of the risk of occupational exposure of healthcare workers to cytotoxic drugs and facilitate the identification of priority areas for specific interventions.
ETHICS AND DISSEMINATION
The systematic review methodology does not require ethics approval due to the nature of the study design. The results of the systematic review will be published in a peer-reviewed journal and will be publicly available.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO CRD42020162780 , dated July 14, 2020.
Identifiants
pubmed: 33076972
doi: 10.1186/s13643-020-01494-4
pii: 10.1186/s13643-020-01494-4
pmc: PMC7574301
doi:
Substances chimiques
Pharmaceutical Preparations
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
242Références
PLoS Med. 2009 Jul 21;6(7):e1000100
pubmed: 19621070
Arch Environ Occup Health. 2017 Sep 3;72(5):289-298
pubmed: 27603111
J Occup Environ Med. 2014 Sep;56(9):901-10
pubmed: 25153300
J Oncol Pharm Pract. 2019 Jul;25(5):1089-1098
pubmed: 29726786
Arch Public Health. 2014 Nov 10;72(1):39
pubmed: 25810908
NTP Monogr. 2019 Mar;(5):
pubmed: 33556047
Am J Health Syst Pharm. 1996 Jul 15;53(14):1669-85
pubmed: 8827233
Environ Int. 2020 Feb;135:105039
pubmed: 31864023
J Oncol Pharm Pract. 2015 Apr;21(2):118-27
pubmed: 24567041
Am J Obstet Gynecol. 2012 Apr;206(4):327.e1-8
pubmed: 22304790
Environ Health Perspect. 2014 Oct;122(10):1007-14
pubmed: 24968373
Cochrane Database Syst Rev. 2019 Oct 3;10:ED000142
pubmed: 31643080
J Occup Environ Hyg. 2016 Sep;13(9):658-67
pubmed: 27019141
Syst Rev. 2015 Jan 01;4:1
pubmed: 25554246