Mutations in

Animals Antitubercular Agents / pharmacology Mice Mutation Mycobacterium tuberculosis / genetics Nitroimidazoles / pharmacology Oxazoles
cofactor F420 mouse model nitroimidazole resistance tuberculosis

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
16 12 2020
Historique:
received: 09 09 2020
accepted: 07 10 2020
pubmed: 21 10 2020
medline: 22 6 2021
entrez: 20 10 2020
Statut: epublish

Résumé

The nitroimidazole prodrugs delamanid and pretomanid comprise one of only two new antimicrobial classes approved to treat tuberculosis (TB) in 50 years. Prior

Identifiants

DOI: 10.1128/AAC.01948-20 PMID: 33077652 PMC: PMC7927868
pubmed: 33077652
pii: AAC.01948-20
doi: 10.1128/AAC.01948-20
pmc: PMC7927868
pii:
doi:

Substances chimiques

Antitubercular Agents 0
Nitroimidazoles 0
OPC-67683 0
Oxazoles 0
pretomanid 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI111992
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142735
Pays : United States

Informations de copyright

Copyright © 2020 American Society for Microbiology.

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Auteurs

Dalin Rifat (D)

Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Si-Yang Li (SY)

Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Thomas Ioerger (T)

Department of Computer Science, Texas A&M University, College Station, Texas, USA.

Keshav Shah (K)

Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Jean-Philippe Lanoix (JP)

Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Department of Infectious Diseases, Amiens University Hospital, Amiens, France.
ORCID: 0000-0003-0463-4636

Jin Lee (J)

Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Ghader Bashiri (G)

Laboratory of Structural Biology and Maurice Wilkins Center for Molecular Biodiscovery, School of Biological Sciences, University of Auckland, Auckland, New Zealand.

James Sacchettini (J)

Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA.

Eric Nuermberger (E)

Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA enuermb@jhmi.edu.
ORCID: 0000-0003-1440-9889

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mutations in
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antituberculeux › Mutations in
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mutations in
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutations in
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Mutations in
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Nitroimidazoles › Mutations in
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Oxazoles › Mutations in