Chloroquine Potentiates Primaquine Activity against Active and Latent Hepatic Plasmodia
chemotherapy
chloroquine
hepatic parasites
latent infection
malaria
potentiation
primaquine
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
16 12 2020
16 12 2020
Historique:
received:
04
07
2020
accepted:
12
10
2020
pubmed:
21
10
2020
medline:
22
6
2021
entrez:
20
10
2020
Statut:
epublish
Résumé
For a long while, 8-aminoquinoline compounds have been the only therapeutic agents against latent hepatic malaria parasites. These have poor activity against the blood-stage plasmodia causing acute malaria and must be used in conjunction with partner blood schizontocidal agents. We examined the impacts of one such agent, chloroquine, upon the activity of primaquine, an 8-aminoquinoline, against hepatic stages of
Identifiants
pubmed: 33077656
pii: AAC.01416-20
doi: 10.1128/AAC.01416-20
pmc: PMC7927800
pii:
doi:
Substances chimiques
Antimalarials
0
Chloroquine
886U3H6UFF
Primaquine
MVR3634GX1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 Dembélé et al.
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