Socio-demographic and trauma-related predictors of PTSD within 8 weeks of a motor vehicle collision in the AURORA study.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
23
10
2019
accepted:
02
10
2020
revised:
18
09
2020
pubmed:
21
10
2020
medline:
27
1
2022
entrez:
20
10
2020
Statut:
ppublish
Résumé
This is the initial report of results from the AURORA multisite longitudinal study of adverse post-traumatic neuropsychiatric sequelae (APNS) among participants seeking emergency department (ED) treatment in the aftermath of a traumatic life experience. We focus on n = 666 participants presenting to EDs following a motor vehicle collision (MVC) and examine associations of participant socio-demographic and participant-reported MVC characteristics with 8-week posttraumatic stress disorder (PTSD) adjusting for pre-MVC PTSD and mediated by peritraumatic symptoms and 2-week acute stress disorder (ASD). Peritraumatic Symptoms, ASD, and PTSD were assessed with self-report scales. Eight-week PTSD prevalence was relatively high (42.0%) and positively associated with participant sex (female), low socioeconomic status (education and income), and several self-report indicators of MVC severity. Most of these associations were entirely mediated by peritraumatic symptoms and, to a lesser degree, ASD, suggesting that the first 2 weeks after trauma may be a uniquely important time period for intervening to prevent and reduce risk of PTSD. This observation, coupled with substantial variation in the relative strength of mediating pathways across predictors, raises the possibility of diverse and potentially complex underlying biological and psychological processes that remain to be elucidated with more in-depth analyses of the rich and evolving AURORA data.
Identifiants
pubmed: 33077855
doi: 10.1038/s41380-020-00911-3
pii: 10.1038/s41380-020-00911-3
pmc: PMC8053721
mid: NIHMS1634660
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3108-3121Subventions
Organisme : NICHD NIH HHS
ID : R01 HD079076
Pays : United States
Organisme : NIMH NIH HHS
ID : K00 MH119603
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NICHD NIH HHS
ID : R03 HD094577
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH110925
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH118467
Pays : United States
Informations de copyright
© 2020. The Author(s), under exclusive licence to Springer Nature Limited.
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