The role of DNA damage response in amyotrophic lateral sclerosis.
DNA damage response
Frontotemporal dementia
Genome instability
Neurodegeneration
Repeat expansion
amyotrophic lateral sclerosis
Journal
Essays in biochemistry
ISSN: 1744-1358
Titre abrégé: Essays Biochem
Pays: England
ID NLM: 0043306
Informations de publication
Date de publication:
26 10 2020
26 10 2020
Historique:
received:
07
07
2020
revised:
28
09
2020
accepted:
29
09
2020
pubmed:
21
10
2020
medline:
8
6
2021
entrez:
20
10
2020
Statut:
ppublish
Résumé
Amyotrophic lateral sclerosis (ALS) is a rapidly disabling and fatal neurodegenerative disease. Due to insufficient disease-modifying treatments, there is an unmet and urgent need for elucidating disease mechanisms that occur early and represent common triggers in both familial and sporadic ALS. Emerging evidence suggests that impaired DNA damage response contributes to age-related somatic accumulation of genomic instability and can trigger or accelerate ALS pathological manifestations. In this review, we summarize and discuss recent studies indicating a direct link between DNA damage response and ALS. Further mechanistic understanding of the role genomic instability is playing in ALS disease pathophysiology will be critical for discovering new therapeutic avenues.
Identifiants
pubmed: 33078197
pii: 226703
doi: 10.1042/EBC20200002
pmc: PMC7588667
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
847-861Subventions
Organisme : Medical Research Council
Pays : United Kingdom
Informations de copyright
© 2020 The Author(s).
Références
J Biol Chem. 2013 Apr 5;288(14):9860-6
pubmed: 23423380
Neuropathology. 2019 Aug;39(4):268-278
pubmed: 31124187
DNA Repair (Amst). 2019 Feb;74:51-62
pubmed: 30630676
Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7701-E7709
pubmed: 27849576
Front Neurosci. 2019 May 15;13:486
pubmed: 31156371
Neuron. 2014 Jul 16;83(2):266-282
pubmed: 25033177
Cell. 2015 Aug 27;162(5):1066-77
pubmed: 26317470
Nature. 2015 Sep 3;525(7567):129-33
pubmed: 26308899
Nature. 2011 Aug 21;477(7363):211-5
pubmed: 21857683
Nat Struct Mol Biol. 2011 Nov 27;18(12):1345-50
pubmed: 22120668
Handb Clin Neurol. 2018;147:105-123
pubmed: 29325606
Am J Pathol. 2008 Jul;173(1):182-94
pubmed: 18535185
Nucleic Acids Res. 2017 Jul 27;45(13):8026-8045
pubmed: 28575377
Inflamm Regen. 2019 Apr 26;39:8
pubmed: 31057688
Nat Rev Neurol. 2017 Aug;13(8):477-491
pubmed: 28731040
Elife. 2018 Jul 13;7:
pubmed: 30003873
Curr Opin Cell Biol. 2013 Jun;25(3):378-86
pubmed: 23567027
J Biol Chem. 2018 Jan 26;293(4):1353-1362
pubmed: 29217771
PLoS Genet. 2017 Mar 16;13(3):e1006635
pubmed: 28301478
Int J Radiat Biol. 2009 Aug;85(8):643-55
pubmed: 19579069
Brain. 2010 Aug;133(Pt 8):2295-312
pubmed: 20639548
Cell. 2009 Jan 23;136(2):284-95
pubmed: 19167330
Ann Neurol. 2007 Dec;62(6):553-9
pubmed: 18074357
Neuron. 2016 Oct 19;92(2):383-391
pubmed: 27720481
Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4696-4705
pubmed: 30770445
Nat Neurosci. 2007 Nov;10(11):1387-94
pubmed: 17965659
Nat Rev Dis Primers. 2017 Oct 05;3:17071
pubmed: 28980624
Brain. 2014 Jul;137(Pt 7):2040-51
pubmed: 24866055
Nature. 2014 Mar 13;507(7491):195-200
pubmed: 24598541
Science. 2009 Feb 27;323(5918):1208-1211
pubmed: 19251628
Mol Cell. 2017 Jun 15;66(6):801-817
pubmed: 28622525
Neurol Genet. 2019 Apr 23;5(3):e335
pubmed: 31086828
EMBO J. 2020 Feb 17;39(4):e100574
pubmed: 31930538
Cell Death Dis. 2019 Jul 18;10(8):550
pubmed: 31320608
Genes Dev. 2016 Oct 1;30(19):2152-2157
pubmed: 27798842
Nat Cell Biol. 2009 Nov;11(11):1376-82
pubmed: 19783983
Nat Struct Mol Biol. 2010 Sep;17(9):1144-51
pubmed: 20802485
Hum Genet. 2016 Aug;135(8):851-67
pubmed: 27215579
Nucleic Acids Res. 2016 Oct 14;44(18):8870-8884
pubmed: 27574117
DNA Repair (Amst). 2013 Aug;12(8):578-87
pubmed: 23721970
Acta Biochim Biophys Sin (Shanghai). 2015 Oct;47(10):834-41
pubmed: 26290490
Gene. 2008 Aug 1;419(1-2):75-81
pubmed: 18555620
J Biol Chem. 2013 Aug 23;288(34):24731-41
pubmed: 23833192
Brain Behav. 2017 Mar 15;7(4):e00669
pubmed: 28413711
Brain. 2013 Aug;136(Pt 8):2419-31
pubmed: 23884810
Cell Cycle. 2015;14(5):712-20
pubmed: 25590687
Neuron. 2013 Aug 7;79(3):416-38
pubmed: 23931993
Nat Genet. 2018 Apr;50(4):603-612
pubmed: 29507424
Brain. 2018 May 1;141(5):1320-1333
pubmed: 29562314
Hum Mol Genet. 2019 Apr 01;28(15):2459-2476
pubmed: 31067307
Acta Neuropathol Commun. 2019 Feb 12;7(1):18
pubmed: 30755280
J Neurosci. 2005 Aug 17;25(33):7567-74
pubmed: 16107644
Curr Biol. 2016 Jan 11;26(1):129-36
pubmed: 26725200
Exp Mol Med. 2020 Apr;52(4):643-657
pubmed: 32284536
Hum Mol Genet. 2015 Mar 1;24(5):1363-73
pubmed: 25343993
Sci Transl Med. 2017 May 3;9(388):
pubmed: 28469040
Neurosci Res. 2018 Jan;126:31-38
pubmed: 29054467
Mutat Res. 2003 Oct 29;531(1-2):231-51
pubmed: 14637258
Elife. 2017 May 02;6:
pubmed: 28463106
J Exp Med. 2018 May 7;215(5):1287-1299
pubmed: 29622565
Mol Brain. 2019 Dec 4;12(1):103
pubmed: 31801573
Cell. 2009 Mar 20;136(6):1001-4
pubmed: 19303844
Nucleic Acids Res. 2014;42(16):10473-87
pubmed: 25147206
J Exp Neurosci. 2019 Jun 10;13:1179069519856358
pubmed: 31217692
Nature. 1993 Jun 17;363(6430):640-4
pubmed: 8510758
Acta Neuropathol. 2013 Sep;126(3):385-99
pubmed: 23836290
Mol Cancer Res. 2010 Oct;8(10):1388-98
pubmed: 20858735
Nature. 1993 Mar 4;362(6415):59-62
pubmed: 8446170
Nat Rev Cancer. 2014 Apr;14(4):233-47
pubmed: 24658274
Am J Hum Genet. 2004 Jun;74(6):1128-35
pubmed: 15106121
Neurology. 2003 Mar 11;60(5):813-9
pubmed: 12629239
PLoS Genet. 2019 May 17;15(5):e1007947
pubmed: 31100073
Proc Natl Acad Sci U S A. 2019 May 7;116(19):9628-9633
pubmed: 31019093
Nature. 1997 Aug 28;388(6645):839-40
pubmed: 9278044
Nat Commun. 2017 Sep 13;8(1):530
pubmed: 28904350
Lancet. 2017 Nov 4;390(10107):2084-2098
pubmed: 28552366
Cell Rep. 2013 Dec 12;5(5):1178-86
pubmed: 24290757
Biochem Biophys Res Commun. 2012 Feb 3;418(1):116-21
pubmed: 22244893
Nat Commun. 2019 Jan 8;10(1):87
pubmed: 30622252
Lancet Neurol. 2013 Feb;12(2):207-16
pubmed: 23332364
Nat Rev Neurol. 2015 May;11(5):266-79
pubmed: 25896087
Lancet Neurol. 2012 Jan;11(1):42-53
pubmed: 22137354
Nat Genet. 1993 Jun;4(2):175-80
pubmed: 7503811
Autophagy. 2017 Jan 2;13(1):212-213
pubmed: 27791533
Science. 2008 Mar 21;319(5870):1668-72
pubmed: 18309045
Neurobiol Aging. 2017 Mar;51:178.e1-178.e9
pubmed: 28017481
Front Oncol. 2014 May 19;4:96
pubmed: 24904820
Acta Neuropathol. 2013 Dec;126(6):829-44
pubmed: 24129584
Acta Neuropathol. 2018 Sep;136(3):425-443
pubmed: 29725819
Nat Neurosci. 2015 Sep;18(9):1226-9
pubmed: 26308983
Neuron. 2013 Oct 16;80(2):415-28
pubmed: 24139042
Trends Immunol. 2004 Dec;25(12):677-86
pubmed: 15530839
Nat Rev Dis Primers. 2017 Oct 20;3:17085
pubmed: 29052611
Proc Natl Acad Sci U S A. 1985 Jun;82(12):4245-9
pubmed: 3159021
Nat Mater. 2020 Apr;19(4):464-473
pubmed: 31844279
Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4530-9
pubmed: 24170860
Cell. 1997 Aug 8;90(3):537-48
pubmed: 9267033
Science. 2019 Feb 15;363(6428):
pubmed: 30765536
Nature. 2009 Oct 22;461(7267):1071-8
pubmed: 19847258
Nat Genet. 2016 Sep;48(9):1043-8
pubmed: 27455348
Mol Biol Cell. 2003 Sep;14(9):3664-74
pubmed: 12972555
Science. 2009 Feb 27;323(5918):1205-8
pubmed: 19251627
Genes Dev. 2017 Nov 15;31(22):2204-2221
pubmed: 29284710
J Pharmacol Sci. 2015 Jan;127(1):36-41
pubmed: 25704016
Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E4968-77
pubmed: 24248382
Hum Mol Genet. 2017 Aug 1;26(15):2882-2896
pubmed: 28481984
Nat Neurosci. 2015 May;18(5):631-6
pubmed: 25803835
Lancet Neurol. 2018 Jan;17(1):94-102
pubmed: 29154141
Nat Rev Neurol. 2010 Apr;6(4):211-20
pubmed: 20234357
Nat Rev Mol Cell Biol. 2013 Apr;14(4):197-210
pubmed: 23486281
Lancet Neurol. 2015 Jan;14(1):57-64
pubmed: 25435387
Curr Biol. 2019 Oct 7;29(19):3135-3152.e4
pubmed: 31495585
Curr Pharm Des. 2017;23(33):5010-5021
pubmed: 28641533
J Biol Chem. 1997 Jul 25;272(30):18515-7
pubmed: 9228011
Front Mol Biosci. 2018 Feb 13;5:8
pubmed: 29487852
Elife. 2016 Sep 13;5:
pubmed: 27623008
Int J Mol Sci. 2018 Oct 12;19(10):
pubmed: 30322030
Neuron. 2004 Feb 19;41(4):549-61
pubmed: 14980204
Neuron. 2013 Feb 20;77(4):639-46
pubmed: 23415312
Cell Rep. 2019 Feb 26;26(9):2298-2306.e5
pubmed: 30811981
Amyotroph Lateral Scler. 2009 Aug;10(4):237-43
pubmed: 18821088
Cell Res. 2016 Sep;26(9):1033-47
pubmed: 27325298
Neuropathol Appl Neurobiol. 2015 Aug;41(5):578-97
pubmed: 25487060
Brain. 2018 May 1;141(5):1247-1262
pubmed: 29584802
Neurobiol Dis. 2010 Aug;39(2):198-203
pubmed: 20399857
Science. 2013 Feb 15;339(6121):786-91
pubmed: 23258413
Acta Neuropathol. 2013 Dec;126(6):845-57
pubmed: 24170096
Acta Neuropathol Commun. 2014 Dec 10;2:172
pubmed: 25492614
J Biol Chem. 2016 Nov 4;291(45):23464-23476
pubmed: 27634045
Sci Rep. 2012;2:1016
pubmed: 23264878
Nucleic Acids Res. 2015 Jul 13;43(12):5971-83
pubmed: 25999341
Brain Pathol. 2020 Mar;30(2):283-297
pubmed: 31376192
Nat Rev Neurol. 2018 Sep;14(9):544-558
pubmed: 30120348
Genes Dev. 2011 Feb 1;25(3):220-5
pubmed: 21289067
J Clin Med. 2019 May 22;8(5):
pubmed: 31121901
Mol Brain. 2017 Feb 2;10(1):5
pubmed: 28148298
Cell Cycle. 2010 Apr 15;9(8):1568-76
pubmed: 20421735
Mol Cell. 2016 Oct 6;64(1):189-198
pubmed: 27716483
Brain. 2019 May 1;142(5):1176-1194
pubmed: 30938443
Nat Cell Biol. 2018 Aug;20(8):954-965
pubmed: 30022119
Nature. 2016 Jan 7;529(7584):48-53
pubmed: 26700805
Neurobiol Aging. 2012 Apr;33(4):837.e7-13
pubmed: 22078486
Nature. 2004 Jun 24;429(6994):883-91
pubmed: 15190254
Nature. 2010 Aug 26;466(7310):1069-75
pubmed: 20740007
EMBO J. 2019 Oct 4;38(21):e102361
pubmed: 31613024
J Neurochem. 2016 Aug;138 Suppl 1:95-111
pubmed: 27015757
Adv Biol Regul. 2016 Sep;62:25-36
pubmed: 26776475
Nat Rev Neurol. 2019 Oct;15(10):565-581
pubmed: 31501588
Mol Cell Biol. 2009 Dec;29(24):6335-40
pubmed: 19805510
Mol Cell. 2010 Oct 22;40(2):179-204
pubmed: 20965415
PLoS One. 2018 May 10;13(5):e0197165
pubmed: 29746542
Lancet. 2011 Mar 12;377(9769):942-55
pubmed: 21296405
Sci Signal. 2012 Mar 06;5(214):ra20
pubmed: 22394562
Nat Commun. 2016 Apr 15;7:11253
pubmed: 27080313
Nature. 2016 Nov 10;539(7628):197-206
pubmed: 27830784
Acta Neuropathol. 2020 Jan;139(1):99-118
pubmed: 31642962
J Biol Chem. 2005 Sep 2;280(35):30783-7
pubmed: 15985438
Nat Neurosci. 2014 Jan;17(1):17-23
pubmed: 24369373
J Neurol. 2010 Jan;257(1):15-23
pubmed: 19629566
Nat Commun. 2014 Mar 19;5:3446
pubmed: 24647101
Prog Neurobiol. 2016 Oct - Nov;145-146:78-97
pubmed: 27693252
EMBO J. 1994 Dec 15;13(24):6087-98
pubmed: 7813445
Stem Cell Res. 2018 Jul;30:150-162
pubmed: 29929116
Nat Commun. 2018 Sep 11;9(1):3683
pubmed: 30206235
Acta Neuropathol Commun. 2019 Oct 28;7(1):166
pubmed: 31661035
Mutagenesis. 2010 Sep;25(5):447-54
pubmed: 20501547
Science. 2013 Mar 15;339(6125):1335-8
pubmed: 23393093
Acta Neuropathol Commun. 2019 Jul 18;7(1):103
pubmed: 31319884
Autophagy. 2016 Oct 2;12(10):1917-1930
pubmed: 27391408
Neuron. 2017 Aug 16;95(4):808-816.e9
pubmed: 28817800
Brain. 2018 Oct 1;141(10):2908-2924
pubmed: 30239641
Science. 1997 Sep 26;277(5334):1990-3
pubmed: 9302293
Nat Neurosci. 2013 Oct;16(10):1383-91
pubmed: 24036913
Nat Commun. 2018 Jan 23;9(1):335
pubmed: 29362359
Lancet Neurol. 2011 Mar;10(3):253-63
pubmed: 21349440
Curr Opin Genet Dev. 2017 Jun;44:117-124
pubmed: 28319737
Nat Med. 2016 Aug;22(8):869-78
pubmed: 27348499
PLoS Genet. 2009 Oct;5(10):e1000684
pubmed: 19834596
J Neurol Neurosurg Psychiatry. 2014 Nov;85(11):1232-8
pubmed: 24648037
Nature. 2015 Jun 11;522(7555):179-84
pubmed: 26017310
Hum Mol Genet. 2016 Mar 15;25(6):1074-87
pubmed: 26755825
J Biol Chem. 2008 May 9;283(19):13302-9
pubmed: 18305110
Neurotherapeutics. 2019 Oct;16(4):948-956
pubmed: 31364066
Acta Neuropathol. 2015 Jul;130(1):77-92
pubmed: 25943890
DNA Repair (Amst). 2015 Aug;32:96-105
pubmed: 26002199
Nucleic Acids Res. 2017 Dec 15;45(22):12862-12876
pubmed: 29140459
Nat Commun. 2016 Aug 11;7:12408
pubmed: 27510634
Nat Neurosci. 2017 Sep;20(9):1225-1235
pubmed: 28714954