Stereoselective Synthesis and Antiallodynic Activity of 3-Hydroxylated Paroxetines.
alkaloids
allodynia
neuropathic pain
paroxetine
stereoselective synthesis
Journal
ChemMedChem
ISSN: 1860-7187
Titre abrégé: ChemMedChem
Pays: Germany
ID NLM: 101259013
Informations de publication
Date de publication:
04 02 2021
04 02 2021
Historique:
received:
28
08
2020
revised:
10
10
2020
pubmed:
21
10
2020
medline:
11
11
2021
entrez:
20
10
2020
Statut:
ppublish
Résumé
The design, stereoselective synthesis and in vivo antiallodynic activity of four novel paroxetine analogs, named 3-hydroxy paroxetines (3HPXs), is reported herein. Among the novel synthesized compounds, three showed an antiallodynic effect, while (R,R)-3HPX was found to be 2.5 times more bioactive than (-)-paroxetine itself in neuropathic rats. Consequently, the current investigation not only discloses a novel promising analgesic drug, but also reveals that functionalization at the C3 position of paroxetine could be as effective as the common functionalization at either C4 or within the sesamol group.
Identifiants
pubmed: 33078572
doi: 10.1002/cmdc.202000674
doi:
Substances chimiques
Analgesics
0
Paroxetine
41VRH5220H
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
472-476Subventions
Organisme : Consejo Nacional de Ciencia y Tecnología (CONACyT)
ID : A1-S-21450
Informations de copyright
© 2020 Wiley-VCH GmbH.
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