Assessment of the

Anti-Bacterial Agents / pharmacology Cytochrome P-450 Enzyme Inhibitors / pharmacology Cytochrome P-450 Enzyme System Humans Ketolides / pharmacology Lactones / pharmacology Microsomes, Liver / drug effects
k inact/K I CYP inhibition MBI Nafithromycin TDI WCK 4873 ketolides macrolides

Journal

Xenobiotica; the fate of foreign compounds in biological systems
ISSN: 1366-5928
Titre abrégé: Xenobiotica
Pays: England
ID NLM: 1306665

Informations de publication

Date de publication:
Mar 2021
Historique:
pubmed: 21 10 2020
medline: 4 3 2021
entrez: 20 10 2020
Statut: ppublish

Résumé

Nafithromycin is a next generation lactone ketolide antibiotic slated to enter phase III clinical development in India for the treatment of CABP as a shorter 800 mg-OD X3 day therapeutic regimen. Nafithromycin exhibits potent activity against MDR

Identifiants

DOI: 10.1080/00498254.2020.1839983 PMID: 33078993
pubmed: 33078993
doi: 10.1080/00498254.2020.1839983
doi:

Substances chimiques

Anti-Bacterial Agents 0
Cytochrome P-450 Enzyme Inhibitors 0
Ketolides 0
Lactones 0
nafithromycin 75F74Y2R70
Cytochrome P-450 Enzyme System 9035-51-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

251-261

Auteurs

Rajesh Chavan (R)

Wockhardt Research Centre, Aurangabad, India.
ORCID: 0000-0001-5611-5251

Vineet Zope (V)

Wockhardt Research Centre, Aurangabad, India.

Nilesh Chavan (N)

Wockhardt Research Centre, Aurangabad, India.

Kiran Patil (K)

Wockhardt Research Centre, Aurangabad, India.
ORCID: 0000-0002-0597-1303

Ravindra Yeole (R)

Wockhardt Research Centre, Aurangabad, India.
ORCID: 0000-0003-4812-4259

Sachin Bhagwat (S)

Wockhardt Research Centre, Aurangabad, India.
ORCID: 0000-0001-5943-5031

Mahesh Patel (M)

Wockhardt Research Centre, Aurangabad, India.
ORCID: 0000-0002-5128-4061

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Assessment of the
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs des enzymes du cytochrome P-450 › Assessment of the
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Assessment of the
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Assessment of the
questionsmedicales.fr › Composés chimiques organiques › Lactones › Érythromycine › Cétolides › Assessment of the
questionsmedicales.fr › Composés chimiques organiques › Lactones › Assessment of the
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie › Assessment of the