Microglial reduction of colony stimulating factor-1 receptor expression is sufficient to confer adult onset leukodystrophy.

Csf2 expression GM-CSF adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) axonal pathology colony stimulating factor-1 receptor (CSF-1R) demyelination microgliopathy

Journal

Glia
ISSN: 1098-1136
Titre abrégé: Glia
Pays: United States
ID NLM: 8806785

Informations de publication

Date de publication:
03 2021
Historique:
received: 09 09 2020
revised: 07 10 2020
accepted: 09 10 2020
pubmed: 21 10 2020
medline: 14 1 2022
entrez: 20 10 2020
Statut: ppublish

Résumé

Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a dementia resulting from dominantly inherited CSF1R inactivating mutations. The Csf1r

Identifiants

pubmed: 33079443
doi: 10.1002/glia.23929
pmc: PMC8575656
mid: NIHMS1750240
doi:

Substances chimiques

Receptors, Colony-Stimulating Factor 0
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor 0
Receptor Protein-Tyrosine Kinases EC 2.7.10.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

779-791

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS091519
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS096144
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013330
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD090260
Pays : United States

Informations de copyright

© 2020 Wiley Periodicals LLC.

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Auteurs

Fabrizio Biundo (F)

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA.

Violeta Chitu (V)

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA.

Gabriel G L Shlager (GGL)

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA.

Eun S Park (ES)

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA.

Maria E Gulinello (ME)

Behavioral Core Facility, Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA.

Kusumika Saha (K)

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA.

Harmony C Ketchum (HC)

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA.

Christopher Fernandes (C)

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA.

Şölen Gökhan (Ş)

Institute for Brain Disorders and Neural Regeneration, Departments of Neurology Neuroscience and Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, New York, USA.

Mark F Mehler (MF)

Institute for Brain Disorders and Neural Regeneration, Departments of Neurology Neuroscience and Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, New York, USA.

E Richard Stanley (ER)

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA.

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