Cardiovascular disease in childhood and adolescence: Lessons from children with chronic kidney disease.
arterial calcification
arterial stiffness
cardiovascular disease
chronic kidney disease
intima-media thickness
left ventricular hypertrophy
microvascular rarefaction
Journal
Acta paediatrica (Oslo, Norway : 1992)
ISSN: 1651-2227
Titre abrégé: Acta Paediatr
Pays: Norway
ID NLM: 9205968
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
04
09
2020
revised:
14
10
2020
accepted:
16
10
2020
pubmed:
21
10
2020
medline:
15
5
2021
entrez:
20
10
2020
Statut:
ppublish
Résumé
Children suffering from chronic kidney disease (CKD) have the apparent highest risk for the development of cardiovascular disease (CVD) at a young age. While symptoms of CVD are characteristically absent in childhood and adolescence, remodelling of the myocardium, medium and large-sized arteries and of the microcirculation is clinically significant and can be assessed with non-invasive technology. Kidney disease and its progression are the driver of CVD, mediated by an unparalleled accumulation of risk factors converging on several comorbid conditions including hypertension, anaemia, dyslipidaemia, disturbed mineral metabolism and chronic persistent inflammation. Large prospective paediatric cohorts studies have provided valuable insights into the pathogenesis and the progression of CKD-induced cardiovascular comorbidity and have characterised the cardiovascular phenotype in young patients. They have also provided the rationale for close monitoring of risk factors and have defined therapeutic targets. Recently discovered new biomarkers could help identify the individual risk for CVD. Prevention of CVD by aggressive therapy of modifiable risk factors is essential to enable long-term survival of young patients with CKD.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1125-1131Informations de copyright
© 2020 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.
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