Metabolomic Associations with Serum Bone Turnover Markers.

Adult Bile Acids and Salts / metabolism Biomarkers / blood Bone Remodeling / physiology Collagen Type I / blood Female Gastrointestinal Microbiome / physiology Humans Male Metabolome Micronutrients / metabolism Nutritional Physiological Phenomena / physiology Osteoblasts Osteoclasts Osteogenesis / physiology Peptide Fragments / blood Peptides / blood Procollagen / blood Vitamins / metabolism
bone metabolism microbiome nutrition osteoblast osteoclast

Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
16 Oct 2020
Historique:
received: 21 09 2020
revised: 13 10 2020
accepted: 14 10 2020
entrez: 21 10 2020
pubmed: 22 10 2020
medline: 20 4 2021
Statut: epublish

Résumé

Bone is a dynamic tissue that is in a constant state of remodeling. Bone turnover markers (BTMs), procollagen type I N-terminal propeptide (P1NP) and C-terminal telopeptides of type I collagen (CTX), provide sensitive measures of bone formation and resorption, respectively. This study used ultra-high-resolution metabolomics (HRM) to determine plasma metabolic pathways and targeted metabolites related to the markers of bone resorption and formation in adults. This cross-sectional clinical study included 34 adults (19 females, mean 27.8 years), without reported illnesses, recruited from a US metropolitan area. Serum BTM levels were quantified by an ELISA. Plasma HRM utilized dual-column liquid chromatography and mass spectrometry to identify metabolites and metabolic pathways associated with BTMs. Metabolites significantly associated with P1NP (

Identifiants

DOI: 10.3390/nu12103161 PMID: 33081124 PMC: PMC7602719
pubmed: 33081124
pii: nu12103161
doi: 10.3390/nu12103161
pmc: PMC7602719
pii:
doi:

Substances chimiques

Bile Acids and Salts 0
Biomarkers 0
Collagen Type I 0
Micronutrients 0
Peptide Fragments 0
Peptides 0
Procollagen 0
Vitamins 0
collagen type I trimeric cross-linked peptide 0
procollagen Type I N-terminal peptide 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : P30 ES019776
Pays : United States
Organisme : NIH HHS
ID : R01 AR068157
Pays : United States
Organisme : NIH HHS
ID : K24 DK096574
Pays : United States
Organisme : NIH HHS
ID : R01 DK108842
Pays : United States
Organisme : Office of Academic Affiliations, Department of Veterans Affairs
ID : 5I01BX000105
Organisme : NIEHS NIH HHS
ID : P30 ES019776
Pays : United States
Organisme : NIH HHS
ID : R21 AG065977
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008602
Pays : United States
Organisme : NIH HHS
ID : U54 AG062334
Pays : United States
Organisme : NIH HHS
ID : UL1 TR002378
Pays : United States
Organisme : NIH HHS
ID : R01 AR070091
Pays : United States
Organisme : NIH HHS
ID : R03 AG066559
Pays : United States
Organisme : NIH HHS
ID : R01 DK112946
Pays : United States

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Auteurs

Moriah P Bellissimo (MP)

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Emory Center for Clinical and Molecular Nutrition, Emory University, Atlanta, GA 30322, USA.

Joseph L Roberts (JL)

Department of Orthopaedics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Atlanta Department of Veterans Affairs Medical Center, Decatur, GA 30033, USA.
ORCID: 0000-0001-6839-1173

Dean P Jones (DP)

Emory Center for Clinical and Molecular Nutrition, Emory University, Atlanta, GA 30322, USA.
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

Ken H Liu (KH)

Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

Kaitlin R Taibl (KR)

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

Karan Uppal (K)

Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

M Neale Weitzmann (MN)

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Atlanta Department of Veterans Affairs Medical Center, Decatur, GA 30033, USA.
Emory Microbiome Research Center, Emory University, Atlanta, GA 30322, USA.

Roberto Pacifici (R)

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Emory Microbiome Research Center, Emory University, Atlanta, GA 30322, USA.

Hicham Drissi (H)

Department of Orthopaedics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Atlanta Department of Veterans Affairs Medical Center, Decatur, GA 30033, USA.

Thomas R Ziegler (TR)

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Emory Center for Clinical and Molecular Nutrition, Emory University, Atlanta, GA 30322, USA.
Atlanta Department of Veterans Affairs Medical Center, Decatur, GA 30033, USA.
Emory Microbiome Research Center, Emory University, Atlanta, GA 30322, USA.

Jessica A Alvarez (JA)

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Emory Center for Clinical and Molecular Nutrition, Emory University, Atlanta, GA 30322, USA.
Emory Microbiome Research Center, Emory University, Atlanta, GA 30322, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Metabolomic Associations with Serum Bone...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Acides et sels biliaires › Metabolomic Associations with Serum Bone...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Metabolomic Associations with Serum Bone...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Remodelage osseux › Metabolomic Associations with Serum Bone...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Collagène › Collagènes fibrillaires › Collagène de type I › Metabolomic Associations with Serum Bone...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Metabolomic Associations with Serum Bone...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Metabolomic Associations with Serum Bone...
questionsmedicales.fr › Métabolisme › Métabolome › Metabolomic Associations with Serum Bone...
questionsmedicales.fr › Aliments et boissons › Aliments › Nutriments › Micronutriments › Metabolomic Associations with Serum Bone...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Metabolomic Associations with Serum Bone...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Ostéoblastes › Metabolomic Associations with Serum Bone...
questionsmedicales.fr › Cellules › Cellules myéloïdes › Ostéoclastes › Metabolomic Associations with Serum Bone...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Ostéogenèse › Metabolomic Associations with Serum Bone...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Fragments peptidiques › Metabolomic Associations with Serum Bone...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Metabolomic Associations with Serum Bone...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Collagène › Procollagène › Metabolomic Associations with Serum Bone...
questionsmedicales.fr › Aliments et boissons › Aliments › Nutriments › Micronutriments › Vitamines › Metabolomic Associations with Serum Bone...