Preclinical Evaluation of the GRPR-Targeting Antagonist RM26 Conjugated to the Albumin-Binding Domain for GRPR-Targeting Therapy of Cancer.

RM26 albumin-binding domain gastrin-releasing peptide receptor gastrin-releasing peptide receptors (GRPR) antagonist prostate cancer targeted therapy

Journal

Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003

Informations de publication

Date de publication:
16 Oct 2020
Historique:
received: 28 09 2020
revised: 12 10 2020
accepted: 14 10 2020
entrez: 21 10 2020
pubmed: 22 10 2020
medline: 22 10 2020
Statut: epublish

Résumé

The targeting of gastrin-releasing peptide receptors (GRPR) was recently proposed for targeted therapy, e.g., radiotherapy. Multiple and frequent injections of peptide-based therapeutic agents would be required due to rapid blood clearance. By conjugation of the GRPR antagonist RM26 (D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH

Identifiants

pubmed: 33081166
pii: pharmaceutics12100977
doi: 10.3390/pharmaceutics12100977
pmc: PMC7594083
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : VINNOVA
ID : 2019/00104
Organisme : Cancerfonden
ID : 2017/425
Organisme : Cancerfonden
ID : 2018/436
Organisme : Cancerfonden
ID : 19 0212 Pj 01H
Organisme : Vetenskapsrådet
ID : 2019-00986
Organisme : Vetenskapsrådet
ID : 2015-02353
Organisme : Vetenskapsrådet
ID : 2016-05207

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Auteurs

Ayman Abouzayed (A)

Department of Medicinal Chemistry, Uppsala University, 751 83 Uppsala, Sweden.

Hanna Tano (H)

Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, AlbaNova University Center, 106 91 Stockholm, Sweden.

Ábel Nagy (Á)

Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, AlbaNova University Center, 106 91 Stockholm, Sweden.

Sara S Rinne (SS)

Department of Medicinal Chemistry, Uppsala University, 751 83 Uppsala, Sweden.

Fadya Wadeea (F)

Department of Medicinal Chemistry, Uppsala University, 751 83 Uppsala, Sweden.

Sharmishtaa Kumar (S)

Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, AlbaNova University Center, 106 91 Stockholm, Sweden.

Kristina Westerlund (K)

Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, AlbaNova University Center, 106 91 Stockholm, Sweden.

Vladimir Tolmachev (V)

Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.
Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk 634050, Russia.

Amelie Eriksson Karlström (A)

Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, AlbaNova University Center, 106 91 Stockholm, Sweden.

Anna Orlova (A)

Department of Medicinal Chemistry, Uppsala University, 751 83 Uppsala, Sweden.
Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk 634050, Russia.
Science for Life Laboratory, Uppsala University, 751 05 Uppsala, Sweden.

Classifications MeSH