Candidate drug replacements for quinacrine in cutaneous lupus erythematosus.
autoimmune diseases
lupus erythematosus
methotrexate
systemic
Journal
Lupus science & medicine
ISSN: 2053-8790
Titre abrégé: Lupus Sci Med
Pays: England
ID NLM: 101633705
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
22
07
2020
revised:
22
09
2020
accepted:
01
10
2020
entrez:
21
10
2020
pubmed:
22
10
2020
medline:
23
9
2021
Statut:
ppublish
Résumé
Cutaneous lupus erythematosus (CLE) is a disfiguring and potentially disabling disease that causes significant morbidity in patients. Antimalarials are an important class of medication used to treat this disease and have been the first-line systemic therapy since the 1950s. Quinacrine, in particular, is used as an adjuvant therapy to other antimalarials for improved control of CLE. Quinacrine is currently unavailable in the USA, which has taken away an important component of the treatment regimen of patients with CLE. This paper reviews the evidence of available local and systemic therapies in order to assist providers in choosing alternative treatments for patients who previously benefited from quinacrine therapy.
Identifiants
pubmed: 33082164
pii: 7/1/e000430
doi: 10.1136/lupus-2020-000430
pmc: PMC7577055
pii:
doi:
Substances chimiques
Antimalarials
0
Pharmaceutical Preparations
0
Quinacrine
H0C805XYDE
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR071653
Pays : United States
Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: DY, RB and RDS have nothing to disclose. VPW reports personal fees from Genentech, Medimmune, Amgen, Resolve, Lilly, Principia, BMS, AC, Nektar, EMD Serona, Astra Zeneca, Vielo, Abbvie, Kyowa Kirin, GSK and Cugene, outside the submitted work; grants and personal fees from Biogen, Gilead, Celgene and Janssen; in addition, VPW has patents Cutaneous Lupus Erythematous Disease Area and Severity Index and CDASI with royalties paid.
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