Low Advanced Lung Cancer Inflammation Index Predicts Poor Prognosis in Locally Advanced Nasopharyngeal Carcinoma Patients Treated with Definitive Concurrent Chemoradiotherapy.


Journal

Journal of oncology
ISSN: 1687-8450
Titre abrégé: J Oncol
Pays: Egypt
ID NLM: 101496537

Informations de publication

Date de publication:
2020
Historique:
received: 02 05 2020
revised: 18 09 2020
accepted: 25 09 2020
entrez: 21 10 2020
pubmed: 22 10 2020
medline: 22 10 2020
Statut: epublish

Résumé

We aimed to retrospectively investigate the prognostic worth of pretreatment advanced lung cancer inflammation index (ALI) in locally advanced nasopharyngeal carcinoma (LA-NPC) patients treated with concurrent chemoradiotherapy (C-CRT). The ROC curve analyses distinguished a rounded ALI cut-off score of 24.2 that arranged the patients into two cohorts [ALI ≥ 24.2 ( As a novel prognostic index, the pretreatment ALI < 24.2 appeared to be strongly associated with significantly diminished survival outcomes in LA-NPC patients treated with C-CRT independent of the universally recognized T- and N-stages.

Identifiants

pubmed: 33082783
doi: 10.1155/2020/3127275
pmc: PMC7563083
doi:

Types de publication

Journal Article

Langues

eng

Pagination

3127275

Informations de copyright

Copyright © 2020 Erkan Topkan et al.

Déclaration de conflit d'intérêts

The authors declare that they have no conflicts of interest regarding the publication of this paper.

Références

J Hepatol. 2014 Aug;61(2):396-407
pubmed: 24751830
Cancer Med. 2017 Jan;6(1):310-319
pubmed: 27860387
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Medicine (Baltimore). 2017 Jul;96(29):e7577
pubmed: 28723793
J Support Oncol. 2007 Apr;5(4):157-62; discussion 164-6, 183
pubmed: 17500503
Cancer Med. 2018 Dec;7(12):6010-6019
pubmed: 30406969
Crit Rev Oncol Hematol. 2018 Jul;127:91-104
pubmed: 29891116
Lancet Oncol. 2011 May;12(5):489-95
pubmed: 21296615
Acta Haematol. 2017;137(2):76-85
pubmed: 28076862
Jpn J Clin Oncol. 2018 Mar 1;48(3):265-271
pubmed: 29294009
Eur Arch Otorhinolaryngol. 2019 May;276(5):1487-1492
pubmed: 30877423
Asia Pac J Clin Nutr. 2003;12(3):257-60
pubmed: 14505986
J Am Diet Assoc. 2004 Aug;104(8):1258-64
pubmed: 15281044
Clin Otolaryngol. 2020 Mar;45(2):167-176
pubmed: 31573757
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
pubmed: 21296855
Clin Nutr. 2008 Dec;27(6):793-9
pubmed: 18718696
Onco Targets Ther. 2014 Sep 30;7:1811-5
pubmed: 25336972
Carcinogenesis. 2009 Jul;30(7):1073-81
pubmed: 19468060
BMC Cancer. 2019 Mar 18;19(1):241
pubmed: 30885163
Proc Nutr Soc. 1999 Aug;58(3):681-3
pubmed: 10604203
Curr Opin Clin Nutr Metab Care. 2009 May;12(3):223-6
pubmed: 19318937
Acta Otolaryngol. 2017 Jul;137(7):778-785
pubmed: 28125312
Cancer Manag Res. 2019 Oct 07;11:8807-8815
pubmed: 31632140
Ear Nose Throat J. 2019 Jun 10;:145561319856327
pubmed: 31184210
Cell. 2010 Mar 19;140(6):871-82
pubmed: 20303877
Medicine (Baltimore). 2016 Jan;95(2):e2380
pubmed: 26765414
Clin Lung Cancer. 2015 Nov;16(6):e165-71
pubmed: 25922292
Eur J Cancer. 2013 May;49(8):1923-31
pubmed: 23434149
Nature. 2008 Jul 24;454(7203):436-44
pubmed: 18650914
Clin Cancer Res. 2010 Jul 15;16(14):3754-9
pubmed: 20628028
Nat Rev Cancer. 2013 Nov;13(11):759-71
pubmed: 24154716
Future Oncol. 2020 Feb;16(5):117-127
pubmed: 31789058
BMC Cancer. 2013 Mar 27;13:158
pubmed: 23530866
Crit Rev Oncol Hematol. 2018 Dec;132:130-137
pubmed: 30447918
Tumour Biol. 2011 Apr;32(2):317-24
pubmed: 21052888
Onkologie. 2012;35(9):494-8
pubmed: 23007146
Int J Biol Markers. 2019 Jun;34(2):139-147
pubmed: 30864463
Lancet Oncol. 2014 Oct;15(11):e493-503
pubmed: 25281468

Auteurs

Erkan Topkan (E)

Baskent University Medical Faculty, Department of Radiation Oncology, Adana, Turkey.

Yurday Ozdemir (Y)

Baskent University Medical Faculty, Department of Radiation Oncology, Adana, Turkey.

Ahmet Kucuk (A)

Mersin City Hospital, Radiation Oncology Clinics, Mersin, Turkey.

Ozan Cem Guler (OC)

Baskent University Medical Faculty, Department of Radiation Oncology, Adana, Turkey.

Ahmet Sezer (A)

Baskent University Medical Faculty, Department of Medical Oncology, Adana, Turkey.

Ali Ayberk Besen (AA)

Baskent University Medical Faculty, Department of Medical Oncology, Adana, Turkey.

Huseyin Mertsoylu (H)

Baskent University Medical Faculty, Department of Medical Oncology, Adana, Turkey.

Sukran Senyurek (S)

Koc University, School of Medicine, Department of Radiation Oncology, Istanbul, Turkey.

Nulifer Kilic Durankus (N)

Koc University, School of Medicine, Department of Radiation Oncology, Istanbul, Turkey.

Yasemin Bolukbasi (Y)

Koc University, School of Medicine, Department of Radiation Oncology, Istanbul, Turkey.

Ugur Selek (U)

Koc University, School of Medicine, Department of Radiation Oncology, Istanbul, Turkey.
The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, Houston, TX, USA.

Berrin Pehlivan (B)

Bahcesehir University, Department of Radiation Oncology, Istanbul, Turkey.

Classifications MeSH