Anticancer Activity of a Novel High Phenolic Sorghum Bran in Human Colon Cancer Cells.
Activating Transcription Factor 3
/ genetics
Antineoplastic Agents, Phytogenic
/ pharmacology
Apoptosis
/ drug effects
Cell Line, Tumor
Cell Proliferation
/ drug effects
Colonic Neoplasms
/ metabolism
DNA Damage
/ drug effects
Extracellular Signal-Regulated MAP Kinases
/ genetics
Humans
JNK Mitogen-Activated Protein Kinases
/ genetics
Phenols
/ isolation & purification
Plant Extracts
/ chemistry
S Phase Cell Cycle Checkpoints
/ drug effects
Sorghum
/ chemistry
Up-Regulation
/ drug effects
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2020
2020
Historique:
received:
24
03
2020
revised:
23
07
2020
accepted:
10
09
2020
entrez:
21
10
2020
pubmed:
22
10
2020
medline:
14
5
2021
Statut:
epublish
Résumé
Human colon cancer is the third leading cause of mortality in the United States and worldwide. Chemoprevention using diet is widely accepted as a promising approach for cancer management. Numerous population studies indicate a negative correlation between the incidence of colon cancer and consumption of whole grains with a high content of bioactive phenolic compounds. In the current study, we evaluated the anticancer properties of a high phenolic sorghum bran extract prepared using 70% ethanol with 5% citric acid solvent at room temperature. A significant dose-dependent suppression of cell proliferation was observed in human colon cancer cells treated with the high phenolic sorghum bran extract. Apoptosis and S phase growth arrest were induced, while cell migration and invasion were inhibited by this treatment; these effects were accompanied by altered expression of apoptosis, cell cycle, and metastasis-regulating genes. We also found that the high phenolic sorghum bran extract stimulated DNA damage in association with induction of extracellular signal-regulated kinase (ERK) and c-Jun-NH
Identifiants
pubmed: 33082907
doi: 10.1155/2020/2890536
pmc: PMC7556115
doi:
Substances chimiques
ATF3 protein, human
0
Activating Transcription Factor 3
0
Antineoplastic Agents, Phytogenic
0
Phenols
0
Plant Extracts
0
Extracellular Signal-Regulated MAP Kinases
EC 2.7.11.24
JNK Mitogen-Activated Protein Kinases
EC 2.7.11.24
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2890536Informations de copyright
Copyright © 2020 Seong-Ho Lee et al.
Déclaration de conflit d'intérêts
The authors have no conflict of interest to declare.
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