Therapeutic Challenges with Catastrophic Antiphospholipid Antibody Syndrome: A Case Report.
antiphospholipid antibody
caps
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
16 Sep 2020
16 Sep 2020
Historique:
entrez:
21
10
2020
pubmed:
22
10
2020
medline:
22
10
2020
Statut:
epublish
Résumé
Antiphospholipid antibody syndrome (APS) is a multisystem disorder characterized by thromboembolic events in the presence of antiphospholipid antibodies (APLA). Catastrophic antiphospholipid antibody syndrome (CAPS) is an uncommon variant of APS which is associated with widespread coagulopathy that predominantly affects small vessels. Despite maximal treatment, CAPS has a very high mortality rate. We present a case of a 42-year-old woman with a history of APS who presented to our hospital with complaints of epistaxis, hemoptysis, menorrhagia, and shortness of breath. She was diagnosed with CAPS and developed multiorgan failure and sepsis. Despite maximal treatment with immune modulators, she unfortunately succumbed. With this case, we highlight the importance of early recognition of CAPS and review various treatment modalities that have been proven beneficial. Despite these modalities, CAPS remains a therapeutic challenge in many cases and has a high mortality rate.
Identifiants
pubmed: 33083183
doi: 10.7759/cureus.10482
pmc: PMC7567321
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e10482Informations de copyright
Copyright © 2020, Harne et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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