Sex, androgens and regulation of pulmonary AR, TMPRSS2 and ACE2.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
14 Oct 2020
14 Oct 2020
Historique:
entrez:
21
10
2020
pubmed:
22
10
2020
medline:
22
10
2020
Statut:
epublish
Résumé
The sex discordance in COVID-19 outcomes has been widely recognized, with males generally faring worse than females and a potential link to sex steroids. A plausible mechanism is androgen-induced expression of TMPRSS2 and/or ACE2 in pulmonary tissues that may increase susceptibility or severity in males. This hypothesis is the subject of several clinical trials of anti-androgen therapies around the world. Here, we investigated the sex-associated TMPRSS2 and ACE2 expression in human and mouse lungs and interrogated the possibility of pharmacologic modification of their expression with anti-androgens. We found no evidence for increased
Identifiants
pubmed: 33083800
doi: 10.1101/2020.04.21.051201
pmc: PMC7574256
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL103453
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA172382
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA236780
Pays : United States
Organisme : NHLBI NIH HHS
ID : UG1 HL139126
Pays : United States
Commentaires et corrections
Type : UpdateIn
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