Regional Brain Growth Trajectories in Fetuses with Congenital Heart Disease.
Journal
Annals of neurology
ISSN: 1531-8249
Titre abrégé: Ann Neurol
Pays: United States
ID NLM: 7707449
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
17
05
2020
revised:
14
10
2020
accepted:
16
10
2020
pubmed:
22
10
2020
medline:
3
2
2021
entrez:
21
10
2020
Statut:
ppublish
Résumé
Congenital heart disease (CHD) is associated with abnormal brain development in utero. We applied innovative fetal magnetic resonance imaging (MRI) techniques to determine whether reduced fetal cerebral substrate delivery impacts the brain globally, or in a region-specific pattern. Our novel design included two control groups, one with and the other without a family history of CHD, to explore the contribution of shared genes and/or fetal environment to brain development. From 2014 to 2018, we enrolled 179 pregnant women into 4 groups: "HLHS/TGA" fetuses with hypoplastic left heart syndrome (HLHS) or transposition of the great arteries (TGA), diagnoses with lowest fetal cerebral substrate delivery; "CHD-other," with other CHD diagnoses; "CHD-related," healthy with a CHD family history; and "optimal control," healthy without a family history. Two MRIs were obtained between 18 and 40 weeks gestation. Random effect regression models assessed group differences in brain volumes and relationships to hemodynamic variables. HLHS/TGA (n = 24), CHD-other (50), and CHD-related (34) groups each had generally smaller brain volumes than the optimal controls (71). Compared with CHD-related, the HLHS/TGA group had smaller subplate (-13.3% [standard error = 4.3%], p < 0.01) and intermediate (-13.7% [4.3%], p < 0.01) zones, with a similar trend in ventricular zone (-7.1% [1.9%], p = 0.07). These volumetric reductions were associated with lower cerebral substrate delivery. Fetuses with CHD, especially those with lowest cerebral substrate delivery, show a region-specific pattern of small brain volumes and impaired brain growth before 32 weeks gestation. The brains of fetuses with CHD were more similar to those of CHD-related than optimal controls, suggesting genetic or environmental factors also contribute. ANN NEUROL 2021;89:143-157.
Identifiants
pubmed: 33084086
doi: 10.1002/ana.25940
pmc: PMC7970443
mid: NIHMS1674075
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
143-157Subventions
Organisme : NINDS NIH HHS
ID : R01 NS106030
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23HL141602
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL141602
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD090255
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01EB013248
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB018988
Pays : United States
Organisme : NINDS NIH HHS
ID : K23 NS101120
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB013248
Pays : United States
Informations de copyright
© 2020 American Neurological Association.
Références
Front Hum Neurosci. 2013 Mar 26;7:97
pubmed: 23532379
Circulation. 2010 Jan 5;121(1):26-33
pubmed: 20026783
J Am Heart Assoc. 2019 Aug 6;8(15):e012711
pubmed: 31331224
Nat Neurosci. 2015 May;18(5):773-8
pubmed: 25821911
Nature. 2013 Jun 13;498(7453):220-3
pubmed: 23665959
Front Neuroanat. 2016 Feb 24;10:11
pubmed: 26941612
IEEE Trans Med Imaging. 2015 Sep;34(9):1901-13
pubmed: 25807565
J Thorac Cardiovasc Surg. 2019 May;157(5):1982-1991
pubmed: 30745051
AJNR Am J Neuroradiol. 2013 Mar;34(3):634-40
pubmed: 23042920
Dev Neurosci. 2017;39(1-4):171-181
pubmed: 28434006
Cereb Cortex. 2019 Jul 22;29(8):3605-3616
pubmed: 30272144
Cereb Cortex. 2013 Dec;23(12):2932-43
pubmed: 22977063
Dev Sci. 2012 Jul;15(4):516-27
pubmed: 22709401
J Thorac Cardiovasc Surg. 2013 Sep;146(3):543-9.e1
pubmed: 23375991
Circulation. 2016 Feb 9;133(6):566-75
pubmed: 26769743
AJNR Am J Neuroradiol. 2018 Jun;39(6):1164-1169
pubmed: 29674414
Am Heart J. 2013 Apr;165(4):544-550.e1
pubmed: 23537971
Pediatrics. 2016 Apr;137(4):
pubmed: 26952506
Pediatrics. 2016 Aug;138(2):
pubmed: 27464676
Pediatrics. 2004 Nov;114(5):1362-4
pubmed: 15520122
Pediatr Res. 2017 Jun;81(6):881-890
pubmed: 28157834
Circ Cardiovasc Imaging. 2017 Nov;10(11):e006459
pubmed: 29141840
Pediatr Res. 2013 May;73(5):661-7
pubmed: 23407116
Pediatr Cardiol. 2003 Sep-Oct;24(5):436-43
pubmed: 14627309
Cereb Cortex. 2015 Sep;25(9):2683-95
pubmed: 24722771
J Environ Health. 2014 Jan-Feb;76(6):130-8
pubmed: 24645424
Brain Struct Funct. 2011 Jan;215(3-4):255-63
pubmed: 21046152
J Am Coll Cardiol. 2002 Jun 19;39(12):1890-900
pubmed: 12084585
J Neurosci. 2003 Apr 15;23(8):3308-15
pubmed: 12716938
BMC Neurosci. 2016 Jan 05;17:2
pubmed: 26733225
J Thorac Cardiovasc Surg. 2019 Aug 28;:
pubmed: 31597618
Ment Retard Dev Disabil Res Rev. 2000;6(1):1-5
pubmed: 10899791
Am Heart J. 2018 Jul;201:33-39
pubmed: 29910053
Child Neuropsychol. 2020 Feb;26(2):170-188
pubmed: 31385559
Child Dev. 2013 Jan-Feb;84(1):58-75
pubmed: 21883162
J Am Heart Assoc. 2018 Dec 18;7(24):e010395
pubmed: 30561261
Circulation. 2015 Apr 14;131(15):1313-23
pubmed: 25762062
Brain Behav. 2016 Jun 09;6(8):e00504
pubmed: 27547505
Neuroimage Clin. 2018;20:913-922
pubmed: 30308377
Radiology. 2019 Jul;292(1):159-169
pubmed: 31084478
J Neurosci. 2019 Feb 20;39(8):1365-1373
pubmed: 30587541
J Neurosci. 2017 Dec 6;37(49):11912-11929
pubmed: 29089437
Cereb Cortex. 2002 May;12(5):536-44
pubmed: 11950771
J Neurosci. 2002 Jan 15;22(2):455-63
pubmed: 11784790
Nat Rev Neurosci. 2008 Feb;9(2):110-22
pubmed: 18209730
Sci Transl Med. 2017 Jan 25;9(374):
pubmed: 28123074
Nat Rev Neurosci. 2015 Mar;16(3):133-46
pubmed: 25697157
Placenta. 2015 Sep;36(9):1024-30
pubmed: 26190037
Sci Rep. 2017 Mar 28;7(1):476
pubmed: 28352082
Science. 2015 Dec 4;350(6265):1262-6
pubmed: 26785492