ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription.
Wnt signaling
chromatin remodeling
chromosomes
developmental biology
epo transcription
gene expression
human
liver physiopathology
mouse
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
21 10 2020
21 10 2020
Historique:
received:
12
11
2019
accepted:
20
10
2020
pubmed:
22
10
2020
medline:
15
4
2021
entrez:
21
10
2020
Statut:
epublish
Résumé
Erythropoietin (EPO) is a key regulator of erythropoiesis. The embryonic liver is the main site of erythropoietin synthesis, after which the kidney takes over. The adult liver retains the ability to express EPO, and we discovered here new players of this transcription, distinct from the classical hypoxia-inducible factor pathway. In mice, genetically invalidated in hepatocytes for the chromatin remodeler
Identifiants
pubmed: 33084574
doi: 10.7554/eLife.53550
pii: 53550
pmc: PMC7641585
doi:
pii:
Substances chimiques
ARID1A protein, human
0
DNA-Binding Proteins
0
Transcription Factors
0
beta Catenin
0
Erythropoietin
11096-26-7
Banques de données
GEO
['GSE134553']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agence Nationale de la Recherche
ID : Labex Who Am I"; Idex "EpilivCan""
Pays : International
Organisme : Ligue Contre le Cancer
ID : Equipe Labellisée
Pays : International
Organisme : Agence Nationale de la Recherche
ID : Idex "EpilivCan"
Pays : International
Organisme : Institut National Du Cancer
ID : Chromaliv
Pays : International
Organisme : Institut National Du Cancer
ID : Epigenetics and Liver Cancer
Pays : International
Organisme : NHLBI NIH HHS
ID : R01 HL139735
Pays : United States
Organisme : Agence Nationale de la Recherche
ID : Labex "Who Am I"
Pays : International
Informations de copyright
© 2020, Riou et al.
Déclaration de conflit d'intérêts
RR, ML, SG, PB, AG, CG, RL, IL, FL, JC, AD, ZW, FV, SC No competing interests declared
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