Family history and pelvic organ prolapse: a systematic review and meta-analysis.
Family history
Meta-analysis
Pelvic organ prolapse
Primary prolapse
Prolapse recurrence
Systematic review
Journal
International urogynecology journal
ISSN: 1433-3023
Titre abrégé: Int Urogynecol J
Pays: England
ID NLM: 101567041
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
10
07
2020
accepted:
02
10
2020
pubmed:
22
10
2020
medline:
3
7
2021
entrez:
21
10
2020
Statut:
ppublish
Résumé
Numerous analytic observational studies assess family history as a risk factor for POP and report a wide range of associations. This review aims to systematically evaluate the role of family history of POP in relation to POP risk and its recurrence. A review was performed of the PubMed/MEDLINE database with search criteria specifying family history, risk factors, POP, and their synonyms as title/abstract keywords, as well as MESH terms, up to March 2020. We aggregated evidence across studies with fixed effects (FE) and random effects (RE) meta-analysis. Forty-three articles underwent full-text review. Eighteen independent studies evaluating the relationship between family history of POP and POP risk in 3639 POP cases and 10,912 controls were eligible for meta-analysis. Four studies evaluating family history and POP recurrence in 224 recurrent cases and 400 non-recurrent cases were eligible for inclusion into another meta-analyses. A positive family history of POP is on average associated with 2.3- to 2.7-fold increased risk for POP (RE OR = 2.64; 95% CI = 2.07, 3.35) as well as a 1.4-fold increased risk for POP recurrence (FE OR = 1.44; 95% CI = 1.00, 2.08). Meta-analysis estimates of POP risk varied by study design, definition of family history, and model adjustment status. We found evidence that publication bias and recall bias are a possibility. Family history of POP is a risk factor for both POP presence and recurrence. However, reported magnitudes may be overestimates due to confounding, recall bias, and publication bias.
Identifiants
pubmed: 33084962
doi: 10.1007/s00192-020-04559-z
pii: 10.1007/s00192-020-04559-z
pmc: PMC8086380
mid: NIHMS1639951
doi:
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
759-774Subventions
Organisme : NIDDK NIH HHS
ID : K01 DK120631
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD043483
Pays : United States
Organisme : NIDDK NIH HHS
ID : 1K01DK120631-01A1
Pays : United States
Organisme : Building Interdisciplinary Research Careers in Women's Health (PI: Katherine Hartmann)
ID : 2K12HD043483
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