Anti-inflammatory and Cytoprotective Effect of Clinacanthus nutans Leaf But Not Stem Extracts on 7-Ketocholesterol Induced Brain Endothelial Cell Injury.

Acanthaceae / chemistry Anti-Inflammatory Agents / pharmacology Brain / cytology Cell Line Chromatography, High Pressure Liquid Cyclooxygenase 2 / biosynthesis Cytokines / biosynthesis Cytoprotection Dose-Response Relationship, Drug Drug Evaluation, Preclinical Endothelial Cells / drug effects Gene Expression Regulation / drug effects Humans Ketocholesterols / toxicity Plant Extracts / pharmacology Plant Leaves / chemistry Plant Stems / chemistry Plants, Medicinal / chemistry RNA, Messenger / biosynthesis
Diabetes mellitus Hypercholesterolemia Neuroinflammation Oxysterols Sabah snake grass Vascular dementia

Journal

Neuromolecular medicine
ISSN: 1559-1174
Titre abrégé: Neuromolecular Med
Pays: United States
ID NLM: 101135365

Informations de publication

Date de publication:
03 2021
Historique:
received: 13 08 2020
accepted: 08 10 2020
pubmed: 22 10 2020
medline: 23 11 2021
entrez: 21 10 2020
Statut: ppublish

Résumé

Clinacanthus nutans (Lindau) (C. nutans) has diverse uses in traditional herbal medicine for treating skin rashes, insect and snake bites, lesions caused by herpes simplex virus, diabetes mellitus and gout in Singapore, Malaysia, Indonesia, Thailand and China. We previously showed that C. nutans has the ability to modulate the induction of cytosolic phospholipase A

Identifiants

DOI: 10.1007/s12017-020-08621-3 PMID: 33085066
pubmed: 33085066
doi: 10.1007/s12017-020-08621-3
pii: 10.1007/s12017-020-08621-3
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Cytokines 0
Ketocholesterols 0
Plant Extracts 0
RNA, Messenger 0
Cyclooxygenase 2 EC 1.14.99.1
7-ketocholesterol O7676FE78M

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

176-183

Références

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Auteurs

Xuan Kuo (X)

Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119260, Singapore.

Deron R Herr (DR)

Department of Biology, San Diego State University, San Diego, CA, 92182, USA. dherr@sdsu.edu.
ORCID: 0000-0001-5755-0896

Wei-Yi Ong (WY)

Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119260, Singapore. antongwy@nus.edu.sg.
Neurobiology Programme, Life Sciences Institute, National University of Singapore, Singapore, 119260, Singapore. antongwy@nus.edu.sg.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lamiales › Acanthaceae › Anti-inflammatory and Cytoprotective Effect of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Anti-inflammatory and Cytoprotective Effect of...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Anti-inflammatory and Cytoprotective Effect of...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Anti-inflammatory and Cytoprotective Effect of...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Anti-inflammatory and Cytoprotective Effect of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Cyclooxygenase 2 › Anti-inflammatory and Cytoprotective Effect of...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Anti-inflammatory and Cytoprotective Effect of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Cytoprotection › Anti-inflammatory and Cytoprotective Effect of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Anti-inflammatory and Cytoprotective Effect of...
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questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Anti-inflammatory and Cytoprotective Effect of...
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questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Anti-inflammatory and Cytoprotective Effect of...