A flexible method for optimising sharing of healthcare resources and demand in the context of the COVID-19 pandemic.


Journal

PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081

Informations de publication

Date de publication:
2020
Historique:
received: 13 07 2020
accepted: 22 09 2020
entrez: 21 10 2020
pubmed: 22 10 2020
medline: 3 11 2020
Statut: epublish

Résumé

As the number of cases of COVID-19 continues to grow, local health services are at risk of being overwhelmed with patients requiring intensive care. We develop and implement an algorithm to provide optimal re-routing strategies to either transfer patients requiring Intensive Care Units (ICU) or ventilators, constrained by feasibility of transfer. We validate our approach with realistic data from the United Kingdom and Spain. In the UK, we consider the National Health Service at the level of trusts and define a 4-regular geometric graph which indicates the four nearest neighbours of any given trust. In Spain we coarse-grain the healthcare system at the level of autonomous communities, and extract similar contact networks. Through random search optimisation we identify the best load sharing strategy, where the cost function to minimise is based on the total number of ICU units above capacity. Our framework is general and flexible allowing for additional criteria, alternative cost functions, and can be extended to other resources beyond ICU units or ventilators. Assuming a uniform ICU demand, we show that it is possible to enable access to ICU for up to 1000 additional cases in the UK in a single step of the algorithm. Under a more realistic and heterogeneous demand, our method is able to balance about 600 beds per step in the Spanish system only using local sharing, and over 1300 using countrywide sharing, potentially saving a large percentage of these lives that would otherwise not have access to ICU.

Identifiants

pubmed: 33085729
doi: 10.1371/journal.pone.0241027
pii: PONE-D-20-21713
pmc: PMC7577502
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0241027

Subventions

Organisme : Medical Research Council
ID : MC_PC_19067
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V038613/1
Pays : United Kingdom

Commentaires et corrections

Type : ErratumIn

Déclaration de conflit d'intérêts

The authors have declared that no competing interests exist.

Références

Lancet. 2020 Apr 11;395(10231):1225-1228
pubmed: 32178769
Intensive Care Med. 2020 May;46(5):837-840
pubmed: 32123994
Intensive Care Med. 2020 May;46(5):833-836
pubmed: 32125458
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
JAMA. 2020 Apr 28;323(16):1545-1546
pubmed: 32167538

Auteurs

Lucas Lacasa (L)

School of Mathematical Sciences, Queen Mary University of London, London, United Kingdom.
Institute for Cross-Disciplinary Physics and Complex Systems IFISC (UIB-CSIC), Palma de Mallorca, Spain.

Robert Challen (R)

EPSRC Centre for Predictive Modelling in Healthcare, University of Exeter, Exeter, Devon, United Kingdom.
Taunton and Somerset NHS Foundation Trust, Taunton, Somerset, United Kingdom.

Ellen Brooks-Pollock (E)

Bristol Medical School: Population Health Sciences, University of Bristol, Bristol, United Kingdom.

Leon Danon (L)

Data Science Institute, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, United Kingdom.
The Alan Turing Institute, British Library, London, United Kingdom.

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Classifications MeSH