Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies.
dietary supplement
meta-analysis
safety
thioctic acid
α-lipoic acid
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
19 Oct 2020
19 Oct 2020
Historique:
received:
19
09
2020
revised:
10
10
2020
accepted:
15
10
2020
entrez:
22
10
2020
pubmed:
23
10
2020
medline:
23
10
2020
Statut:
epublish
Résumé
Alpha-lipoic acid (ALA) is a natural short-chain fatty acid that has attracted great attention in recent years as an antioxidant molecule. However, some concerns have been recently raised regarding its safety profile. To address the issue, we aimed to assess ALA safety profile through a systematic review of the literature and a meta-analysis of the available randomized placebo-controlled clinical studies. The literature search included EMBASE, PubMed Medline, SCOPUS, Google Scholar, and ISI Web of Science by Clarivate databases up to 15th August 2020. Data were pooled from 71 clinical studies, comprising 155 treatment arms, which included 4749 subjects with 2558 subjects treated with ALA and 2294 assigned to placebo. A meta-analysis of extracted data suggested that supplementation with ALA was not associated with an increased risk of any treatment-emergent adverse event (all
Identifiants
pubmed: 33086555
pii: antiox9101011
doi: 10.3390/antiox9101011
pmc: PMC7603186
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Asia Pac J Clin Nutr. 2012;21(1):12-21
pubmed: 22374556
Cerebrovasc Dis. 2011;31(6):615-20
pubmed: 21494032
Endocrinol Diabetes Metab Case Rep. 2020 Jun 4;2020:
pubmed: 32554828
J Nutr. 2001 Mar;131(3s):1120S-3S
pubmed: 11238830
J Nutr. 2015 Apr 1;146(4):889S-896S
pubmed: 26962183
J Physiol Biochem. 2013 Sep;69(3):397-404
pubmed: 23180154
Complement Ther Med. 2018 Dec;41:169-174
pubmed: 30477834
Food Funct. 2019 Aug 1;10(8):4941-4952
pubmed: 31343010
Expert Opin Investig Drugs. 2007 Mar;16(3):291-302
pubmed: 17302524
J Altern Complement Med. 2007 Jun;13(5):577-84
pubmed: 17604563
Nutr Hosp. 2014 Nov 03;31(2):883-9
pubmed: 25617577
Sci Rep. 2017 Nov 10;7(1):15288
pubmed: 29127425
Physiol Res. 2009;58(6):855-61
pubmed: 19093729
Cytokine. 2020 Apr 4;130:155084
pubmed: 32259774
Diabetes Care. 2012 Feb;35(2):196-7
pubmed: 22228743
J Hand Surg Am. 2017 Apr;42(4):236-242
pubmed: 28249792
Food Funct. 2019 Sep 1;10(9):5732-5738
pubmed: 31453617
J Nutr. 2020 Sep 1;150(9):2336-2345
pubmed: 32692358
Ophthalmol Retina. 2020 Sep;4(9):889-898
pubmed: 32418846
J Clin Pharm Ther. 2019 Apr;44(2):258-267
pubmed: 30585337
Pain. 2020 Aug 05;:
pubmed: 32773602
BMJ. 2008 Apr 26;336(7650):924-6
pubmed: 18436948
Eur J Pain. 2009 May;13(5):492-6
pubmed: 18675569
Med Oral Patol Oral Cir Bucal. 2011 Aug 01;16(5):e635-40
pubmed: 20711135
J Oral Rehabil. 2009 Jan;36(1):52-7
pubmed: 18976257
Drugs. 2019 May;79(7):751-766
pubmed: 30989634
Free Radic Biol Med. 1999 Aug;27(3-4):309-14
pubmed: 10468203
Clin Nutr ESPEN. 2019 Aug;32:16-28
pubmed: 31221283
Eur Rev Med Pharmacol Sci. 2017 Sep;21(18):4219-4227
pubmed: 29028075
Pharmacol Res. 2019 May;143:1-16
pubmed: 30844537
Am J Med. 2011 Jan;124(1):85.e1-8
pubmed: 21187189
Oxid Med Cell Longev. 2020 Mar 9;2020:5850865
pubmed: 32256955
Eur J Endocrinol. 2012 Oct;167(4):465-71
pubmed: 22837391
Gut. 1982 Dec;23(12):1088-93
pubmed: 6129179
SAGE Open Med Case Rep. 2018 Dec 26;6:2050313X18819601
pubmed: 30627435
Saudi Med J. 2011 Jun;32(6):584-8
pubmed: 21666939
Headache. 2007 Jan;47(1):52-7
pubmed: 17355494
Antioxidants (Basel). 2018 Nov 12;7(11):
pubmed: 30424472
Nutr Metab Cardiovasc Dis. 2013 Jun;23(6):543-9
pubmed: 22402059
Iran J Pharm Res. 2019 Fall;18(4):2144-2156
pubmed: 32184879
J Diabetes Metab Disord. 2019 Jul 29;18(2):585-595
pubmed: 31890685
Int Clin Psychopharmacol. 2016 Sep;31(5):265-74
pubmed: 27276401
Am J Cardiol. 2017 May 1;119(9):1382-1386
pubmed: 28258730
Clin Microbiol Infect. 2014 Feb;20(2):123-9
pubmed: 24320992
J Cardiol. 2016 Feb;67(2):153-61
pubmed: 26347218
Inflamm Res. 2017 Nov;66(11):947-959
pubmed: 28676917
Gen Pharmacol. 1997 Sep;29(3):315-31
pubmed: 9378235
JAMA. 1998 Nov 11;280(18):1569-75
pubmed: 9820257
Spinal Cord. 2015 Aug;53(8):621-4
pubmed: 25753493
Neuroimmunomodulation. 2014;21(6):291-6
pubmed: 24821457
Ann Nutr Metab. 2012;60(4):293-7
pubmed: 22678104
Diabetes Care. 2006 Nov;29(11):2365-70
pubmed: 17065669
Gynecol Endocrinol. 2019 Mar;35(3):271-275
pubmed: 30303695
J Altern Complement Med. 2008 Mar;14(2):139-46
pubmed: 18315507
Mult Scler. 2005 Apr;11(2):159-65
pubmed: 15794388
Pediatr Diabetes. 2008 Jun;9(3 Pt 2):69-73
pubmed: 18221433
J Obstet Gynaecol Res. 2019 Feb;45(2):313-317
pubmed: 30328246
Circulation. 2005 Jan 25;111(3):343-8
pubmed: 15655130
Clin Nutr. 2020 Jun;39(6):1742-1752
pubmed: 31526611
Int J Clin Pract. 2020 Jun;74(6):e13493
pubmed: 32091656
Asian J Anesthesiol. 2018 Jun;56(2):45-55
pubmed: 30286558
Diabetes Metab J. 2017 Aug;41(4):275-283
pubmed: 28868825
Oxid Med Cell Longev. 2019 Jun 12;2019:3276958
pubmed: 31285784
Int J Endocrinol. 2012;2012:456279
pubmed: 22331979
J Med Food. 2018 May;21(5):521-526
pubmed: 29356576
BMJ. 2009 Jul 21;339:b2535
pubmed: 19622551
Clin Nutr. 2009 Apr;28(2):192-7
pubmed: 19231043
Nutrients. 2019 Feb 12;11(2):
pubmed: 30759784
Electron Physician. 2017 Jul 25;9(7):4899-4905
pubmed: 28894553
J Oral Pathol Med. 2009 Mar;38(3):254-61
pubmed: 19175713
Diabet Med. 2004 Feb;21(2):114-21
pubmed: 14984445
Neurol Neuroimmunol Neuroinflamm. 2017 Jun 28;4(5):e374
pubmed: 28680916
J Ren Nutr. 2012 Mar;22(2):244-50
pubmed: 21908204
Diabetes Care. 2011 Sep;34(9):e146
pubmed: 21868770
Fertil Steril. 2015 Aug;104(2):318-24
pubmed: 26051095
Ann Med Health Sci Res. 2013 Jul;3(3):442-6
pubmed: 24116330
Diabet Med. 1999 Dec;16(12):1040-3
pubmed: 10656234
Arch Gynecol Obstet. 2019 Mar;299(3):665-673
pubmed: 30564928
Int J Cardiol. 2013 Jul 31;167(2):602-3
pubmed: 23102606
Clin Nutr. 2020 Jul 29;:
pubmed: 32778460
Arch Gerontol Geriatr. 2009;49 Suppl 1:129-33
pubmed: 19836626
Diabetes Care. 2011 Sep;34(9):2054-60
pubmed: 21775755
J Chronic Dis. 1956 Dec;4(6):589-99
pubmed: 13376690
Mult Scler J Exp Transl Clin. 2019 May 13;5(2):2055217319850193
pubmed: 31205740
Obesity (Silver Spring). 2015 Feb;23(2):313-21
pubmed: 25594166
Regul Toxicol Pharmacol. 2020 Jul;114:104647
pubmed: 32305367
J Blood Med. 2020 May 07;11:131-139
pubmed: 32494211
Iran J Kidney Dis. 2013 Nov;7(6):461-7
pubmed: 24241092
J Diabetes Res. 2015;2015:474561
pubmed: 26171398
Med Oral Patol Oral Cir Bucal. 2015 Jul 01;20(4):e435-40
pubmed: 26034927
J Oral Pathol Med. 2002 May;31(5):267-9
pubmed: 12110042
Support Care Cancer. 2014 May;22(5):1223-31
pubmed: 24362907
Int Urol Nephrol. 2014 Aug;46(8):1633-8
pubmed: 24729102
Metabolism. 2018 Oct;87:56-69
pubmed: 29990473
Int J Prev Med. 2018 Apr 05;9:34
pubmed: 29721235