Diagnostic test accuracy of point-of-care procalcitonin to diagnose serious bacterial infections in children.
Procalcitonin
bacterial infection
biomarkers
infection
paediatrics
Journal
BMC pediatrics
ISSN: 1471-2431
Titre abrégé: BMC Pediatr
Pays: England
ID NLM: 100967804
Informations de publication
Date de publication:
21 10 2020
21 10 2020
Historique:
received:
26
06
2020
accepted:
13
10
2020
entrez:
22
10
2020
pubmed:
23
10
2020
medline:
15
5
2021
Statut:
epublish
Résumé
The National Institute for Health and Care Excellence (NICE) have called for research into the role of biomarkers, and specifically procalcitonin (PCT), for the early diagnosis of serious bacterial infections (SBI) in children. The aim of this study was to compare the diagnostic test accuracy of C-reactive protein (CRP) and PCT for the diagnosis of SBI in children. Data was collected prospectively from four UK emergency departments (ED) between November 2017 and June 2019. Consecutive children under 18 years of age with fever and features of possible sepsis and/or meningitis were eligible for inclusion. The index tests were PCT and CRP and the reference standard was the confirmation of SBI. 213 children were included in the final analysis. 116 participants (54.5%) were male, and the median age was 2 years, 9 months. Parenteral antibiotics were given to 100 (46.9%), three (1.4%) were admitted to a paediatric intensive care unit and there were no deaths. There were ten (4.7%) confirmed SBI. The area under the curve for PCT and CRP for the detection of SBI was identical at 0.70. There was no difference in the performance of PCT and CRP for the recognition of SBI in this cohort. Registered at https://www.clinicaltrials.gov (trial registration: NCT03378258 ) on the 19th of December 2017.
Sections du résumé
BACKGROUND
The National Institute for Health and Care Excellence (NICE) have called for research into the role of biomarkers, and specifically procalcitonin (PCT), for the early diagnosis of serious bacterial infections (SBI) in children. The aim of this study was to compare the diagnostic test accuracy of C-reactive protein (CRP) and PCT for the diagnosis of SBI in children.
METHODS
Data was collected prospectively from four UK emergency departments (ED) between November 2017 and June 2019. Consecutive children under 18 years of age with fever and features of possible sepsis and/or meningitis were eligible for inclusion. The index tests were PCT and CRP and the reference standard was the confirmation of SBI.
RESULTS
213 children were included in the final analysis. 116 participants (54.5%) were male, and the median age was 2 years, 9 months. Parenteral antibiotics were given to 100 (46.9%), three (1.4%) were admitted to a paediatric intensive care unit and there were no deaths. There were ten (4.7%) confirmed SBI. The area under the curve for PCT and CRP for the detection of SBI was identical at 0.70.
CONCLUSIONS
There was no difference in the performance of PCT and CRP for the recognition of SBI in this cohort.
TRIAL REGISTRATION
Registered at https://www.clinicaltrials.gov (trial registration: NCT03378258 ) on the 19th of December 2017.
Identifiants
pubmed: 33087092
doi: 10.1186/s12887-020-02385-2
pii: 10.1186/s12887-020-02385-2
pmc: PMC7576699
doi:
Substances chimiques
Biomarkers
0
Procalcitonin
0
C-Reactive Protein
9007-41-4
Banques de données
ClinicalTrials.gov
['NCT03378258']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
487Subventions
Organisme : Public Health Agency
ID : EAT/5313/16
Pays : International
Organisme : Royal College of Emergency Medicine
ID : N/A
Pays : International
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