Human DNA ligases in replication and repair.

DNA DNA Damage DNA Ligase ATP / metabolism DNA Repair DNA Replication Humans Poly-ADP-Ribose Binding Proteins / metabolism
DNA joining Okazaki fragments alternative end joining base excision repair non-homologous end joining nucleotide excision repair single strand break reapir

Journal

DNA repair
ISSN: 1568-7856
Titre abrégé: DNA Repair (Amst)
Pays: Netherlands
ID NLM: 101139138

Informations de publication

Date de publication:
09 2020
Historique:
entrez: 22 10 2020
pubmed: 23 10 2020
medline: 25 3 2021
Statut: ppublish

Résumé

To ensure genome integrity, the joining of breaks in the phosphodiester backbone of duplex DNA is required during DNA replication and to complete the repair of almost all types of DNA damage. In human cells, this task is accomplished by DNA ligases encoded by three genes, LIG1, LIG3 and LIG4. Mutations in LIG1 and LIG4 have been identified as the causative factor in two inherited immunodeficiency syndromes. Moreover, there is emerging evidence that DNA ligases may be good targets for the development of novel anti-cancer agents. In this graphical review, we provide an overview of the roles of the DNA ligases encoded by the three human LIG genes in DNA replication and repair.

Identifiants

DOI: 10.1016/j.dnarep.2020.102908 PMID: 33087274 PMC: PMC8727047
pubmed: 33087274
pii: S1568-7864(20)30156-7
doi: 10.1016/j.dnarep.2020.102908
pmc: PMC8727047
mid: NIHMS1627432
pii:
doi:

Substances chimiques

LIG1 protein, human 0
LIG4 protein, human 0
Poly-ADP-Ribose Binding Proteins 0
DNA 9007-49-2
DNA Ligase ATP EC 6.5.1.1
LIG3 protein, human EC 6.5.1.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

102908

Subventions

Organisme : NCI NIH HHS
ID : P30 CA118100
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES012512
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA092584
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM057479
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM047251
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Références

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Auteurs

Annahita Sallmyr (A)

Departments of Internal Medicine, Molecular Genetics and Microbiology and the University of New Mexico Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM 87131, United States.

Ishtiaque Rashid (I)

Departments of Internal Medicine, Molecular Genetics and Microbiology and the University of New Mexico Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM 87131, United States.

Seema Khattri Bhandari (SK)

Departments of Internal Medicine, Molecular Genetics and Microbiology and the University of New Mexico Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM 87131, United States.

Tasmin Naila (T)

Departments of Internal Medicine, Molecular Genetics and Microbiology and the University of New Mexico Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM 87131, United States.

Alan E Tomkinson (AE)

Departments of Internal Medicine, Molecular Genetics and Microbiology and the University of New Mexico Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM 87131, United States. Electronic address: atomkinson@salud.unm.edu.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Human DNA ligases in replication and repair.
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Human DNA ligases in replication and repair.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Polynucleotide ligases › DNA ligases › DNA ligase ATP › Human DNA ligases in replication and repair.
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › Human DNA ligases in replication and repair.
questionsmedicales.fr › Phénomènes génétiques › Réplication de l'ADN › Human DNA ligases in replication and repair.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Human DNA ligases in replication and repair.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › Human DNA ligases in replication and repair.