IMAGINE Network's

Gut microbiome and diet may be important in irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) and comorbid psychiatric conditions, but the mechanisms are unclear. We will create a large cohort of patients with IBS, IBD and healthy controls, and follow them over time, collecting dietary and mental health information and biological samples, to assess their gastrointestinal (GI) and psychological symptoms in association with their diet, gut microbiome and metabolome. This 5-year observational prospective cohort study is recruiting 8000 participants from 15 Canadian centres. Persons with IBS who are 13 years of age and older or IBD ≥5 years will be recruited. Healthy controls will be recruited from the general public and from friends or relatives of those with IBD or IBS who do not have GI symptoms. Participants answer surveys and provide blood, urine and stool samples annually. Surveys assess disease activity, quality of life, physical pain, lifestyle factors, psychological status and diet. The main outcomes evaluated will be the association between the diet, inflammatory, genetic, microbiome and metabolomic profiles in those with IBD and IBS compared with healthy controls using multivariate logistic regression. We will also compare these profiles in those with active versus quiescent disease and those with and without psychological comorbidity. Approval has been obtained from the institutional review boards of all centres taking part in the study. We will develop evidence-based knowledge translation initiatives for patients, clinicians and policymakers to disseminate results to relevant stakeholders.

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Déclaration de conflit d'intérêts

Competing interests: PM holds the Audrey Campbell Chair in Ulcerative Colitis Research. PM, PB and AF have no conflicts of interest. CNB is supported in part by the Bingham Chair in Gastroenterology. He is on Advisory Boards for AbbVie Canada, Janssen Canada, Takeda Canada, Pfizer Canada. He is a consultant for Mylan Pharmaceuticals. He is receiving educational grants from AbbVie Canada, Pfizer Canada, Shire Canada, Takeda Canada, Janssen Canada. Speaker’s panel for AbbVie Canada, Janssen Canada, Takeda Canada, and Medtronic Canada. Received research funding from AbbVie Canada. JDR receives research funding from Pfizer. LAD is on the Advisory Boards for Janssen Canada, AbbVie Canada, Pfizer Canada and Takeda Canada. DAM holds a Canada Research Chair (2008–2018) and the Arthur J.E. Child Chair and receives travel reimbursement through Illumina for meetings of the Global Economics and Evaluation of Clinical Genomics Sequencing Working Group. SV was supported by an educational grant from Allergan. SZ is a patient research partner and received a grant from Takeda Canada.