Role of AMPK/mTOR-independent autophagy in clear cell renal cell carcinoma.
AMP-Activated Protein Kinases
/ metabolism
Aged
Aged, 80 and over
Apoptosis
/ genetics
Autophagy
/ genetics
Carcinoma, Renal Cell
/ genetics
Gene Expression Regulation, Neoplastic
Humans
Kidney Neoplasms
/ genetics
Mechanistic Target of Rapamycin Complex 1
/ metabolism
Middle Aged
Models, Biological
RNA, Messenger
/ genetics
TOR Serine-Threonine Kinases
/ metabolism
apoptosis
carcinoma
cell death
kidney
prognosis
Journal
Journal of investigative medicine : the official publication of the American Federation for Clinical Research
ISSN: 1708-8267
Titre abrégé: J Investig Med
Pays: England
ID NLM: 9501229
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
accepted:
15
09
2020
pubmed:
23
10
2020
medline:
30
9
2021
entrez:
22
10
2020
Statut:
ppublish
Résumé
We examined the status and role of autophagy, a process of lysosomal recycling of cellular material, in clear cell renal cell carcinoma (ccRCC). Paired samples of tumor and adjacent non-malignant tissue were collected from 20 patients with ccRCC after radical nephrectomy. The mRNA levels of apoptosis (
Identifiants
pubmed: 33087428
pii: jim-2020-001524
doi: 10.1136/jim-2020-001524
doi:
Substances chimiques
RNA, Messenger
0
MTOR protein, human
EC 2.7.1.1
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
AMP-Activated Protein Kinases
EC 2.7.11.31
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1386-1393Informations de copyright
© American Federation for Medical Research 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.