COVID-19-Associated Invasive Aspergillosis: Data from the UK National Mycology Reference Laboratory.
Adult
Aged
Aged, 80 and over
Antigens, Fungal
/ blood
Aspergillus fumigatus
/ drug effects
Bronchoalveolar Lavage Fluid
/ microbiology
COVID-19
/ etiology
Critical Illness
Female
Galactose
/ analogs & derivatives
Humans
Invasive Pulmonary Aspergillosis
/ complications
Male
Mannans
/ blood
Middle Aged
Proteoglycans
Real-Time Polymerase Chain Reaction
SARS-CoV-2
United Kingdom
beta-Glucans
/ blood
CAPA
COVID-19
SARS-CoV-2
biomarkers
candidemia
diagnosis
invasive pulmonary aspergillosis
Journal
Journal of clinical microbiology
ISSN: 1098-660X
Titre abrégé: J Clin Microbiol
Pays: United States
ID NLM: 7505564
Informations de publication
Date de publication:
17 12 2020
17 12 2020
Historique:
received:
24
08
2020
accepted:
17
10
2020
pubmed:
23
10
2020
medline:
29
12
2020
entrez:
22
10
2020
Statut:
epublish
Résumé
COVID-19-associated pulmonary aspergillosis (CAPA) was recently reported as a potential infective complication affecting critically ill patients with acute respiratory distress syndrome following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, with incidence rates varying from 8 to 33% depending on the study. However, definitive diagnosis of CAPA is challenging. Standardized diagnostic algorithms and definitions are lacking, clinicians are reticent to perform aerosol-generating bronchoalveolar lavages for galactomannan testing and microscopic and cultural examination, and questions surround the diagnostic sensitivity of different serum biomarkers. Between 11 March and 14 July 2020, the UK National Mycology Reference Laboratory received 1,267 serum and respiratory samples from 719 critically ill UK patients with COVID-19 and suspected pulmonary aspergillosis. The laboratory also received 46 isolates of
Identifiants
pubmed: 33087440
pii: JCM.02136-20
doi: 10.1128/JCM.02136-20
pmc: PMC7771443
pii:
doi:
Substances chimiques
Antigens, Fungal
0
Mannans
0
Proteoglycans
0
beta-Glucans
0
galactomannan
11078-30-1
polysaccharide-K
3X48A86C8K
Galactose
X2RN3Q8DNE
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/N006364/2
Pays : United Kingdom
Informations de copyright
© Crown copyright 2020.
Références
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