Downregulation of CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes by Prolyl Hydroxylase Domain 2 Inhibitors via Hypoxia-Inducible Factor-
Constitutive Androstane Receptor
/ metabolism
Cytochrome P-450 CYP1A2
/ metabolism
Cytochrome P-450 CYP2B6
/ metabolism
Cytochrome P-450 CYP3A
/ metabolism
Down-Regulation
Hepatocytes
/ drug effects
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
/ metabolism
Hypoxia-Inducible Factor-Proline Dioxygenases
/ antagonists & inhibitors
Pregnane X Receptor
/ metabolism
Prolyl-Hydroxylase Inhibitors
/ pharmacokinetics
Protein Stability
Retinoid X Receptors
/ metabolism
Journal
Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
19
05
2020
accepted:
02
10
2020
pubmed:
23
10
2020
medline:
18
1
2022
entrez:
22
10
2020
Statut:
ppublish
Résumé
Hypoxia-inducible factor (HIF) is associated with the expression of CYP, but the underlying mechanism remains uncertain. In this study, we investigated the effect of HIF-
Identifiants
pubmed: 33087449
pii: dmd.120.000124
doi: 10.1124/dmd.120.000124
doi:
Substances chimiques
Constitutive Androstane Receptor
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
NR1I2 protein, human
0
Pregnane X Receptor
0
Prolyl-Hydroxylase Inhibitors
0
Retinoid X Receptors
0
EGLN1 protein, human
EC 1.14.11.2
Hypoxia-Inducible Factor-Proline Dioxygenases
EC 1.14.11.29
CYP1A2 protein, human
EC 1.14.14.1
CYP2B6 protein, human
EC 1.14.14.1
Cytochrome P-450 CYP1A2
EC 1.14.14.1
Cytochrome P-450 CYP2B6
EC 1.14.14.1
Cytochrome P-450 CYP3A
EC 1.14.14.1
CYP3A4 protein, human
EC 1.14.14.55
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
20-30Informations de copyright
Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics.