Simian-Human Immunodeficiency Virus SHIV.C.CH505 Persistence in ART-Suppressed Infant Macaques Is Characterized by Elevated SHIV RNA in the Gut and a High Abundance of Intact SHIV DNA in Naive CD4
Administration, Oral
Animals
Animals, Newborn
Anti-Retroviral Agents
/ therapeutic use
CD4-Positive T-Lymphocytes
/ immunology
DNA, Viral
/ analysis
Disease Reservoirs
Female
HIV Infections
/ immunology
HIV-1
Macaca mulatta
Male
Monkey Diseases
/ immunology
RNA, Viral
/ analysis
Reassortant Viruses
/ immunology
Simian Acquired Immunodeficiency Syndrome
/ immunology
Simian Immunodeficiency Virus
/ immunology
Viral Load
cure
human immunodeficiency virus
nonhuman primates
pediatric
reservoir
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
22 12 2020
22 12 2020
Historique:
received:
21
08
2020
accepted:
14
10
2020
pubmed:
23
10
2020
medline:
17
3
2021
entrez:
22
10
2020
Statut:
epublish
Résumé
Mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) continues to cause new pediatric cases of infection through breastfeeding, a setting where it is not always possible to initiate early antiretroviral therapy (ART). Without novel interventions that do not rely on daily ART, HIV-1-infected children face lifelong medications to control infection. A detailed analysis of virus persistence following breast milk transmission of HIV-1 and ART has not been performed. Here, we used infant rhesus macaques orally infected with simian/human immunodeficiency virus (SHIV) (SHIV.C.CH505) to identify cellular and anatomical sites of virus persistence under ART. Viral DNA was detected at similar levels in blood and tissue CD4
Identifiants
pubmed: 33087463
pii: JVI.01669-20
doi: 10.1128/JVI.01669-20
pmc: PMC7944446
pii:
doi:
Substances chimiques
Anti-Retroviral Agents
0
DNA, Viral
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : T32 AI007392
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI050409
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI131306
Pays : United States
Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA138292
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI131251
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118549
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI131276
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI131331
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI074492
Pays : United States
Informations de copyright
Copyright © 2020 Obregon-Perko et al.
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