Glutaminase Inhibitors Induce Thiol-Mediated Oxidative Stress and Radiosensitization in Treatment-Resistant Cervical Cancers.
Animals
Cell Line, Tumor
Cell Survival
/ drug effects
Disease Models, Animal
Drug Resistance, Neoplasm
/ drug effects
Enzyme Inhibitors
/ pharmacology
Female
Glutaminase
/ antagonists & inhibitors
Glutamine
/ metabolism
Glutathione
/ metabolism
Glycolysis
Humans
Mice
Oxidative Stress
/ drug effects
Phosphatidylinositol 3-Kinases
/ metabolism
Radiation-Sensitizing Agents
/ pharmacology
Reactive Oxygen Species
/ metabolism
Sulfhydryl Compounds
/ metabolism
Uterine Cervical Neoplasms
/ genetics
Xenograft Model Antitumor Assays
Journal
Molecular cancer therapeutics
ISSN: 1538-8514
Titre abrégé: Mol Cancer Ther
Pays: United States
ID NLM: 101132535
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
06
04
2020
revised:
24
07
2020
accepted:
02
10
2020
pubmed:
23
10
2020
medline:
13
8
2021
entrez:
22
10
2020
Statut:
ppublish
Résumé
The purpose of this study was to determine if radiation (RT)-resistant cervical cancers are dependent upon glutamine metabolism driven by activation of the PI3K pathway and test whether PI3K pathway mutation predicts radiosensitization by inhibition of glutamine metabolism. Cervical cancer cell lines with and without PI3K pathway mutations, including SiHa and SiHa PTEN
Identifiants
pubmed: 33087507
pii: 1535-7163.MCT-20-0271
doi: 10.1158/1535-7163.MCT-20-0271
pmc: PMC8208465
mid: NIHMS1636672
doi:
Substances chimiques
Enzyme Inhibitors
0
Radiation-Sensitizing Agents
0
Reactive Oxygen Species
0
Sulfhydryl Compounds
0
Glutamine
0RH81L854J
Glutaminase
EC 3.5.1.2
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2465-2475Subventions
Organisme : NCI NIH HHS
ID : P30 CA086862
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA181745
Pays : United States
Organisme : NIEHS NIH HHS
ID : R35 ES028365
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA217797
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES005605
Pays : United States
Informations de copyright
©2020 American Association for Cancer Research.
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