Drug-induced cholestasis assay in primary hepatocytes.

Drug candidate selection Drug safety evaluation Drug-induced cholestasis Drug-induced liver injury In vitro toxicity Primary hepatocytes

Journal

MethodsX
ISSN: 2215-0161
Titre abrégé: MethodsX
Pays: Netherlands
ID NLM: 101639829

Informations de publication

Date de publication:
2020
Historique:
received: 15 07 2020
accepted: 23 09 2020
entrez: 22 10 2020
pubmed: 23 10 2020
medline: 23 10 2020
Statut: epublish

Résumé

Drug-induced cholestasis (DIC) is a major cause of clinical failure of drug candidates. Numerous patients worldwide are affected when exposed to marketed drugs exhibiting a DIC signature. Prospective identification of DIC during early compound development remains challenging. Here we describe the optimized

Identifiants

pubmed: 33088729
doi: 10.1016/j.mex.2020.101080
pii: S2215-0161(20)30300-9
pmc: PMC7559231
doi:

Types de publication

Journal Article

Langues

eng

Pagination

101080

Informations de copyright

© 2020 The Author(s). Published by Elsevier B.V.

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Auteurs

Pieter Van Brantegem (P)

KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium.

Sagnik Chatterjee (S)

Pharmaceutical Candidate Optimization, Biocon, Bristol-Myers Squibb R& D Center (BBRC), Syngene International Ltd., Bangalore, India.

Tom De Bruyn (T)

Department of Drug Metabolism and Pharmacokinetics, Genentech Inc, South San Francisco, CA, USA.

Pieter Annaert (P)

KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium.

Neel Deferm (N)

KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium.

Classifications MeSH