Once Weekly Application of Urea 40% and Bifonazole 1% Leads to Earlier Nail Removal in Onychomycosis.
AGISPOR ONYCHOSET
Bifonazole
Chemical avulsion
Keratoplastic agent
Nail sealing
Nail treatment
Onychomycosis
Urea
Journal
Skin appendage disorders
ISSN: 2296-9195
Titre abrégé: Skin Appendage Disord
Pays: Switzerland
ID NLM: 101670617
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
31
03
2020
accepted:
26
05
2020
entrez:
22
10
2020
pubmed:
23
10
2020
medline:
23
10
2020
Statut:
ppublish
Résumé
Onychomycosis is a chronic nail fungal infection resulting in nail damage and a decreased quality of life. Chemical avulsion of the nail with urea and bifonazole -removes fungally infected debris, increasing antifungal treatment efficacy and penetration. Previous clinical ob-servations describe patients who applied their urea and -bifonazole ointment less frequently, achieving earlier nail removal. In this study, we analyzed the relationship between duration of urea and bifonazole application and time to nail avulsion. χ Daily application of ointment and sealing resulted in an average length of time (±SD) to nail removal of 18.7 days (±6.8 days); once every 3 days resulted in nail removal at 12.7 days (±6.2 days) and once per week at 11 days (±4.46 days) ( Once weekly application of ointment with sealing for a 1-week duration is associated with a decrease in time to complete chemical avulsion of the nail by approximately 1 week.
Identifiants
pubmed: 33088816
doi: 10.1159/000508926
pii: sad-0006-0304
pmc: PMC7548867
doi:
Types de publication
Journal Article
Langues
eng
Pagination
304-308Informations de copyright
Copyright © 2020 by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
A.K. Gupta is a coordinating investigator for Moberg Pharma and Bausch Health Canada and a speaker for Bausch Health Canada. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Other authors have no conflicts of interest to declare.
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