Multi-time-point data preparation robustly reveals MCI and dementia risk factors.
National Alzheimer's Coordinating Center data
baseline
cardiometabolic risk factors
dementia progression
longitudinal data
mild cognitive impairment (MCI)
multivariate logistic regression
multi‐time‐point data preparation
Journal
Alzheimer's & dementia (Amsterdam, Netherlands)
ISSN: 2352-8729
Titre abrégé: Alzheimers Dement (Amst)
Pays: United States
ID NLM: 101654604
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
06
2020
revised:
05
09
2020
accepted:
16
09
2020
entrez:
22
10
2020
pubmed:
23
10
2020
medline:
23
10
2020
Statut:
epublish
Résumé
Conflicting results on dementia risk factors have been reported across studies. We hypothesize that variation in data preparation methods may partially contribute to this issue. We propose a comprehensive data preparation approach comparing individuals with stable diagnosis over time to those who progress to mild cognitive impairment (MCI)/dementia. This was compared to the often-used "baseline" analysis. Multivariate logistic regression was used to evaluate both methods. The results obtained from sensitivity analyses were consistent with those from our multi-time-point data preparation approach, exhibiting its robustness. Compared to analysis using only baseline data, the number of significant risk factors identified in progression analyses was substantially lower. Additionally, we found that moderate depression increased healthy-to-MCI/dementia risk, while hypertension reduced MCI-to-dementia risk. Overall, multi-time-point-based data preparation approaches may pave the way for a better understanding of dementia risk factors, and address some of the reproducibility issues in the field.
Identifiants
pubmed: 33088897
doi: 10.1002/dad2.12116
pii: DAD212116
pmc: PMC7560502
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12116Subventions
Organisme : NIA NIH HHS
ID : P50 AG005142
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG016573
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG047266
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010161
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG025688
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005133
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005138
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG047366
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG019610
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG028383
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG033514
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG013854
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG053760
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066444
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010124
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG023501
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005131
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010133
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG016574
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005146
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG035982
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG008702
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG016976
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG008051
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005681
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG013846
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG047270
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005136
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG049638
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG012300
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005134
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG008017
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062715
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066468
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010129
Pays : United States
Informations de copyright
© 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
Références
Arch Neurol. 2010 Jan;67(1):107-11
pubmed: 20065137
J Am Geriatr Soc. 2017 Oct;65(10):2198-2204
pubmed: 28771679
Am J Geriatr Psychiatry. 2010 Feb;18(2):98-116
pubmed: 20104067
Sci Rep. 2018 Jun 27;8(1):9774
pubmed: 29950585
J Aging Health. 2010 Apr;22(3):292-306
pubmed: 20103688
Neurology. 2014 Aug 19;83(8):702-9
pubmed: 25080520
Ann Epidemiol. 1998 Jan;8(1):56-63
pubmed: 9465995
Circulation. 2015 Apr 14;131(15):1333-9
pubmed: 25700178
Br J Nutr. 2011 Mar;105(5):747-54
pubmed: 21276278
Int J Geriatr Psychiatry. 2013 Nov;28(11):1109-24
pubmed: 23526458
J Clin Invest. 1948 Jul;27(4):511-4
pubmed: 16695572
BMJ. 2004 Sep 4;329(7465):539
pubmed: 15304383
Cochrane Database Syst Rev. 2009 Oct 07;(4):CD004034
pubmed: 19821318
Int J Epidemiol. 2005 Dec;34(6):1359-68
pubmed: 16051613
Dement Geriatr Cogn Disord. 2009;28(1):75-80
pubmed: 19648749
Alzheimer Dis Assoc Disord. 2004 Oct-Dec;18(4):270-7
pubmed: 15592144
J Thorac Dis. 2016 Sep;8(9):E928-E931
pubmed: 27747028
Lancet Diabetes Endocrinol. 2015 Jun;3(6):431-436
pubmed: 25866264
Neurology. 2010 Nov 23;75(21):1888-95
pubmed: 21068429
Neurobiol Aging. 2001 Jul-Aug;22(4):575-80
pubmed: 11445258
Alzheimers Res Ther. 2019 Jan 5;11(1):1
pubmed: 30611304
PLoS One. 2019 Sep 19;14(9):e0222212
pubmed: 31536538
Curr Clin Pharmacol. 2015;10(3):204-12
pubmed: 26338173
Nature. 2016 May 25;533(7604):452-4
pubmed: 27225100
Neurology. 2013 Jun 4;80(23):2112-20
pubmed: 23658380
Eur Neuropsychopharmacol. 2005 Aug;15(4):463-71
pubmed: 15955676
Maturitas. 2014 Oct;79(2):184-90
pubmed: 24931304
Alzheimers Dement. 2015 Jun;11(6):718-26
pubmed: 26045020
JAMA Psychiatry. 2017 Jan 1;74(1):58-67
pubmed: 27893026
Alzheimer Dis Assoc Disord. 2015 Oct-Dec;29(4):287-93
pubmed: 25626633
J Neurol Neurosurg Psychiatry. 2008 Sep;79(9):979-84
pubmed: 18450788
PLoS One. 2015 Mar 12;10(3):e0118333
pubmed: 25763939
Front Aging Neurosci. 2019 Jun 24;11:146
pubmed: 31293412
Stat Med. 1989 Sep;8(9):1031-40; discussion 1071-3
pubmed: 2678348
Int J Geriatr Psychiatry. 2015 Mar;30(3):234-46
pubmed: 25504093
Curr Opin Psychiatry. 2011 Nov;24(6):461-72
pubmed: 21926624
Front Pharmacol. 2020 Feb 07;11:34
pubmed: 32116710
Ann Indian Acad Neurol. 2010 Dec;13(Suppl 2):S69-73
pubmed: 21369421
J Alzheimers Dis. 2010;22(3):949-58
pubmed: 20858957
Neurology. 1992 Jan;42(1):115-9
pubmed: 1734291
Arch Neurol. 2010 Feb;67(2):187-92
pubmed: 20142526
Alzheimers Dement. 2017 Feb;13(2):103-110
pubmed: 28108119
Lancet Psychiatry. 2016 Jul;3(7):628-35
pubmed: 27138970
Neurobiol Aging. 2003 Jul-Aug;24(4):589-96
pubmed: 12714116
Neurochem Res. 2007 Oct;32(10):1749-56
pubmed: 17705097
Genome Med. 2015 Oct 20;7:106
pubmed: 26482651
Stat Med. 1992 Apr;11(6):783-97
pubmed: 1594817
PLoS One. 2017 Jun 7;12(6):e0178562
pubmed: 28591196