Practical classification of triple-negative breast cancer: intratumoral heterogeneity, mechanisms of drug resistance, and novel therapies.
Breast cancer
Journal
NPJ breast cancer
ISSN: 2374-4677
Titre abrégé: NPJ Breast Cancer
Pays: United States
ID NLM: 101674891
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
04
2020
accepted:
17
09
2020
entrez:
22
10
2020
pubmed:
23
10
2020
medline:
23
10
2020
Statut:
epublish
Résumé
Triple-negative breast cancer (TNBC) is not a unique disease, encompassing multiple entities with marked histopathological, transcriptomic and genomic heterogeneity. Despite several efforts, transcriptomic and genomic classifications have remained merely theoretic and most of the patients are being treated with chemotherapy. Driver alterations in potentially targetable genes, including PIK3CA and AKT, have been identified across TNBC subtypes, prompting the implementation of biomarker-driven therapeutic approaches. However, biomarker-based treatments as well as immune checkpoint inhibitor-based immunotherapy have provided contrasting and limited results so far. Accordingly, a better characterization of the genomic and immune contexture underpinning TNBC, as well as the translation of the lessons learnt in the metastatic disease to the early setting would improve patients' outcomes. The application of multi-omics technologies, biocomputational algorithms, assays for minimal residual disease monitoring and novel clinical trial designs are strongly warranted to pave the way toward personalized anticancer treatment for patients with TNBC.
Identifiants
pubmed: 33088912
doi: 10.1038/s41523-020-00197-2
pii: 197
pmc: PMC7568552
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
54Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsC.C. received speakers’ bureau and consultancy/advisory role from Lilly, Roche Novartis, and Pfizer. G.C. reports personal fees for consulting, advisory role and speakers’ bureau from Roche/Genentech, Novartis, Pfizer, Lilly, Foundation Medicine, Samsung, and Daichii-Sankyo; honoraria from Ellipses Pharma; fees for travel and accommodations from Roche/Genentech, and Pfizer. The remaining authors declare no competing interests.
Références
Nat Commun. 2020 Apr 14;11(1):1787
pubmed: 32286297
Clin Cancer Res. 2015 Nov 15;21(22):5131-8
pubmed: 26106073
Cancer Discov. 2019 Feb;9(2):176-198
pubmed: 30679171
Nature. 2015 May 28;521(7553):541-544
pubmed: 25799992
Biomedicines. 2017 Aug 22;5(3):
pubmed: 28829404
Nature. 2018 Aug;560(7719):499-503
pubmed: 30051890
Int J Cancer. 2008 Jul 1;123(1):236-40
pubmed: 18398844
Nat Rev Clin Oncol. 2020 Apr;17(4):204-232
pubmed: 31792354
Onco Targets Ther. 2015 Jul 29;8:1941-8
pubmed: 26251616
Ann Oncol. 2020 Mar;31(3):377-386
pubmed: 32067679
J Cancer. 2018 Nov 24;9(24):4627-4634
pubmed: 30588246
JAMA Oncol. 2018 Sep 1;4(9):1207-1213
pubmed: 29879283
Int J Cancer. 2016 May 1;138(9):2274-80
pubmed: 26649807
N Engl J Med. 2018 Nov 29;379(22):2108-2121
pubmed: 30345906
Nat Rev Genet. 2017 Oct;18(10):613-623
pubmed: 28649135
Cell Immunol. 2005 Dec;238(2):67-75
pubmed: 16574086
Sci Transl Med. 2020 Mar 11;12(534):
pubmed: 32161105
Cancer Sci. 2015 Nov;106(11):1582-9
pubmed: 26353837
Int J Mol Cell Med. 2018 Fall;7(4):234-240
pubmed: 31516883
Am J Pathol. 2017 Oct;187(10):2139-2151
pubmed: 28736315
J Clin Oncol. 2011 Aug 1;29(22):3008-15
pubmed: 21709188
Br J Cancer. 2018 Feb 6;118(3):312-324
pubmed: 29123260
Ann Oncol. 2020 May;31(5):590-598
pubmed: 32245699
Br J Cancer. 2016 Feb 2;114(3):248-55
pubmed: 26742006
Clin Cancer Res. 2017 Jul 15;23(14):3711-3720
pubmed: 28167507
Nature. 2016 Jul 20;535(7612):382-7
pubmed: 27443740
Nat Commun. 2018 Apr 3;9(1):1317
pubmed: 29615613
Signal Transduct Target Ther. 2017;2:
pubmed: 28435746
Oncoimmunology. 2017 Feb 6;6(2):e1253654
pubmed: 28344865
Clin Breast Cancer. 2020 Aug;20(4):e385-e396
pubmed: 32139270
Breast Cancer Res. 2007;9(5):R65
pubmed: 17910759
Ann Oncol. 2018 Jan 1;29(1):154-161
pubmed: 29045554
Nat Med. 2001 Sep;7(9):1028-34
pubmed: 11533706
J Clin Oncol. 2007 Apr 10;25(11):1329-33
pubmed: 17416853
J Clin Oncol. 2020 May 10;38(14):1539-1548
pubmed: 32097092
Sci Transl Med. 2015 Aug 26;7(302):302ra133
pubmed: 26311728
Breast Cancer Res Treat. 2012 Nov;136(2):331-45
pubmed: 23073759
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8418-23
pubmed: 12829800
Mod Pathol. 2006 Feb;19(2):264-71
pubmed: 16341146
Clin Cancer Res. 2019 Apr 15;25(8):2523-2536
pubmed: 30538112
Anticancer Agents Med Chem. 2008 Oct;8(7):790-7
pubmed: 18855580
Clin Cancer Res. 2021 Jul 15;27(14):3896-3904
pubmed: 33602685
Nat Rev Clin Oncol. 2020 Jun;17(6):341-348
pubmed: 32112054
JAMA. 2015 Apr 7;313(13):1347-61
pubmed: 25849179
Cancer Cell. 2019 Mar 18;35(3):428-440.e5
pubmed: 30853353
Int J Clin Exp Pathol. 2012;5(8):806-13
pubmed: 23071863
Cell. 2012 May 25;149(5):979-93
pubmed: 22608084
Cancer Res. 2012 Nov 1;72(21):5454-62
pubmed: 22933060
J Clin Oncol. 2016 Jul 20;34(21):2460-7
pubmed: 27138582
Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17041-6
pubmed: 24085845
Lancet Oncol. 2018 Apr;19(4):497-509
pubmed: 29501363
Oncotarget. 2016 Jan 5;7(1):193-208
pubmed: 26506594
Nat Med. 2019 Jun;25(6):920-928
pubmed: 31086347
Breast Cancer Res Treat. 2017 Jun;163(2):241-254
pubmed: 28299476
Int J Cancer. 2015 May 1;136(9):2158-65
pubmed: 25307450
Nat Cancer. 2020 Apr;1(4):382-393
pubmed: 32864625
Nature. 2005 Apr 14;434(7035):917-21
pubmed: 15829967
J Clin Oncol. 2012 Jan 1;30(1):19-26
pubmed: 22147742
Nature. 2019 May;569(7757):560-564
pubmed: 31118521
Breast Cancer Res. 2018 Aug 2;20(1):82
pubmed: 30071865
EMBO Mol Med. 2015 Aug;7(8):1034-47
pubmed: 25987569
BMC Med. 2019 May 9;17(1):90
pubmed: 31068190
NPJ Breast Cancer. 2019 Aug 29;5:27
pubmed: 31482107
Cancer Discov. 2016 Dec;6(12):1315-1333
pubmed: 27872127
J Clin Oncol. 2017 Jul 1;35(19):2193-2202
pubmed: 28471727
PLoS One. 2016 Jun 16;11(6):e0157368
pubmed: 27310713
Clin Cancer Res. 2015 Apr 1;21(7):1688-98
pubmed: 25208879
Lancet Oncol. 2017 Dec;18(12):e731-e741
pubmed: 29208439
Ann Oncol. 2016 May;27(5):812-8
pubmed: 27052658
Cancer Chemother Pharmacol. 2007 Jan;59(1):79-87
pubmed: 16642371
Breast Cancer Res. 2010;12(5):R68
pubmed: 20813035
Breast Cancer Res Treat. 2019 Jan;173(2):275-288
pubmed: 30306430
Nature. 2012 Oct 4;490(7418):61-70
pubmed: 23000897
Nat Rev Clin Oncol. 2016 Nov;13(11):674-690
pubmed: 27184417
Clin Cancer Res. 2010 Feb 1;16(3):876-87
pubmed: 20103682
Histopathology. 2006 Jul;49(1):22-34
pubmed: 16842243
Lancet Oncol. 2020 Jan;21(1):44-59
pubmed: 31786121
Nature. 2000 Aug 17;406(6797):747-52
pubmed: 10963602
Nature. 2016 May 02;534(7605):47-54
pubmed: 27135926
Mol Cancer. 2018 Feb 19;17(1):25
pubmed: 29455646
J Clin Oncol. 2014 Dec 1;32(34):3840-7
pubmed: 25349301
Nat Med. 2018 May;24(5):628-637
pubmed: 29713086
Cancer Cell. 2018 Apr 9;33(4):570-580
pubmed: 29634945
Br J Cancer. 2011 May 24;104(11):1730-8
pubmed: 21559013
DNA Repair (Amst). 2018 Nov;71:172-176
pubmed: 30177437
Cancer Discov. 2015 Jul;5(7):704-12
pubmed: 26091828
JAMA Oncol. 2019 Mar 1;5(3):334-342
pubmed: 30347025
Breast Cancer Res Treat. 2018 Nov;172(2):437-444
pubmed: 30132220
Ann Oncol. 2020 May;31(5):569-581
pubmed: 32278621
Oncogene. 2013 Jan 10;32(2):222-33
pubmed: 22349828
Ann Oncol. 2019 Mar 1;30(3):397-404
pubmed: 30475950
NPJ Precis Oncol. 2017;1:
pubmed: 29152592
Cancer Discov. 2017 Jul;7(7):675-693
pubmed: 28630051
JAMA Oncol. 2020 Sep 1;6(9):1410-1415
pubmed: 32644110
Oncotarget. 2017 Nov 30;8(67):111281-111294
pubmed: 29340053
Cancer Treat Rev. 2017 Feb;53:111-119
pubmed: 28104566
Ann Oncol. 2018 Jan 1;29(1):162-169
pubmed: 29077781
Breast Cancer Res Treat. 2018 Feb;167(3):671-686
pubmed: 29063313
Ann Oncol. 2022 May;33(5):534-543
pubmed: 35182721
J Clin Oncol. 2019 Mar 1;37(7):559-569
pubmed: 30650045
Ann Oncol. 2017 Feb 1;28(2):313-320
pubmed: 27803006
Mod Pathol. 2009 Feb;22(2):291-8
pubmed: 19011601
Clin Cancer Res. 2019 Apr 15;25(8):2369-2371
pubmed: 30728154
Clin Cancer Res. 2013 Oct 1;19(19):5505-12
pubmed: 23965901
Cell. 2017 Aug 10;170(4):605-635
pubmed: 28802037
J Immunol. 2010 Nov 1;185(9):4977-82
pubmed: 20962266
N Engl J Med. 2015 Aug 20;373(8):726-36
pubmed: 26287849
Nature. 2015 Feb 12;518(7538):240-4
pubmed: 25409150
Cell. 2018 May 3;173(4):879-893.e13
pubmed: 29681456
Nat Rev Clin Oncol. 2015 Jan;12(1):27-41
pubmed: 25286972
Nature. 2020 Feb;578(7793):94-101
pubmed: 32025018
J Clin Oncol. 2009 Mar 10;27(8):1160-7
pubmed: 19204204
Ann Oncol. 2018 Apr 1;29(4):895-902
pubmed: 29365031
Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18740-4
pubmed: 19841262
Clin Cancer Res. 2005 Jun 15;11(12):4357-64
pubmed: 15958618
J Clin Oncol. 2020 Jun 10;38(17):1887-1896
pubmed: 32058843
J Clin Oncol. 2008 May 20;26(15):2568-81
pubmed: 18487574
Oncologist. 2008;13 Suppl 3:21-6
pubmed: 18458121
Front Oncol. 2014 Apr 14;4:64
pubmed: 24782981
J Breast Cancer. 2017 Jun;20(2):150-159
pubmed: 28690651
Nature. 2017 Nov 23;551(7681):517-520
pubmed: 29132144
N Engl J Med. 2010 Nov 11;363(20):1938-48
pubmed: 21067385
J Pathol. 2013 Feb;229(3):422-9
pubmed: 23165508
Nat Cell Biol. 2019 Sep;21(9):1113-1126
pubmed: 31451770
Cancer Discov. 2020 May;10(5):657-663
pubmed: 32029534
Cancer Cell. 2012 Jul 10;22(1):106-16
pubmed: 22789542
Oncogene. 2008 Jul 3;27(29):4086-95
pubmed: 18332865
Clin Cancer Res. 2017 May 15;23(10):2423-2432
pubmed: 27815358
Lancet Oncol. 2018 Jan;19(1):40-50
pubmed: 29233559
J Clin Oncol. 2015 Jun 10;33(17):1902-9
pubmed: 25847936
Clin Breast Cancer. 2015 Dec;15(6):473-481.e3
pubmed: 26051240
BMC Med Genomics. 2012 Oct 04;5:44
pubmed: 23035882
Breast Cancer Res. 2014 Aug 08;16(4):406
pubmed: 25103565
N Engl J Med. 2017 Dec 21;377(25):2500-2501
pubmed: 29262275
Clin Cancer Res. 2010 Apr 1;16(7):2147-56
pubmed: 20215530
J Clin Oncol. 2015 May 10;33(14):1609-19
pubmed: 25847941
N Engl J Med. 2019 Feb 21;380(8):741-751
pubmed: 30786188
Cell Res. 2002 Mar;12(1):9-18
pubmed: 11942415
JAMA Oncol. 2019 Jan 1;5(1):e183773
pubmed: 30347019
Nat Rev Immunol. 2007 Mar;7(3):202-12
pubmed: 17318231
Clin Cancer Res. 2020 Jun 1;26(11):2565-2572
pubmed: 32019858
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10869-74
pubmed: 11553815
Cell. 2019 Jan 10;176(1-2):404
pubmed: 30633907
Cancer Treat Rev. 2017 Dec;61:15-22
pubmed: 29078133
Clin Cancer Res. 2020 Apr 1;26(7):1712-1724
pubmed: 31848190
Nat Cell Biol. 2018 Aug;20(8):954-965
pubmed: 30022119
Cell Death Dis. 2017 Jun 1;8(6):e2843
pubmed: 28569777
J Clin Oncol. 2018 Feb 20;36(6):543-553
pubmed: 29298117
Front Endocrinol (Lausanne). 2015 Apr 24;6:59
pubmed: 25964777
Nature. 2012 Apr 04;486(7403):395-9
pubmed: 22495314
Nat Rev Cancer. 2011 Jun;11(6):393-410
pubmed: 21606941
Nat Med. 2012 Jul;18(7):1052-9
pubmed: 22683778
Breast Cancer Res. 2015 Jan 21;17:8
pubmed: 25848704
Nature. 2018 Feb 8;554(7691):189-194
pubmed: 29420467
PLoS One. 2009 May 24;4(5):e5676
pubmed: 19479068
Clin Breast Cancer. 2016 Oct;16(5):349-355
pubmed: 27340049
Clin Cancer Res. 2019 Sep 15;25(18):5441-5448
pubmed: 30979742
Nat Commun. 2018 May 10;9(1):1849
pubmed: 29748565
Breast Cancer Res Treat. 2013 Feb;137(3):773-82
pubmed: 23288347
Nat Commun. 2018 Sep 4;9(1):3588
pubmed: 30181541
N Engl J Med. 2017 Aug 10;377(6):523-533
pubmed: 28578601
Nature. 2013 Oct 17;502(7471):333-339
pubmed: 24132290
J Clin Oncol. 2018 Mar 20;36(9):884-890
pubmed: 29373071
Nat Commun. 2017 Nov 24;8(1):1751
pubmed: 29170499
Oncogene. 2007 Mar 29;26(14):2126-32
pubmed: 17016441
Nature. 2013 Aug 22;500(7463):415-21
pubmed: 23945592
Cancer Discov. 2016 Feb;6(2):202-16
pubmed: 26645196
Nature. 2017 Jan 18;541(7637):321-330
pubmed: 28102259
Br J Cancer. 2009 Jan 27;100(2):405-11
pubmed: 19165203
Nat Rev Cancer. 2016 Feb;16(2):110-20
pubmed: 26775620
Ann Oncol. 2016 Feb;27(2):249-56
pubmed: 26598540
Nat Rev Cancer. 2017 Apr;17(4):223-238
pubmed: 28233803
Cancer Discov. 2017 Sep;7(9):999-1005
pubmed: 28450426
Ann Oncol. 2019 Dec 1;30(12):1941-1949
pubmed: 31566659
Nature. 2008 Feb 28;451(7182):1116-20
pubmed: 18264087
J Natl Cancer Inst. 2003 Oct 1;95(19):1482-5
pubmed: 14519755
J Exp Med. 2016 Dec 12;213(13):2835-2840
pubmed: 27903604
Nature. 2018 Aug;560(7716):117-121
pubmed: 30022168
Ann Oncol. 2019 Dec 1;30(Suppl_10):x3-x11
pubmed: 31859348
Cancer Discov. 2012 Nov;2(11):1036-47
pubmed: 22915752
JAMA Oncol. 2019 Aug 01;5(8):1132-1140
pubmed: 31194225
Lancet Oncol. 2020 Oct;21(10):1269-1282
pubmed: 32861273
Clin Cancer Res. 2017 Aug 1;23(15):4035-4045
pubmed: 28270498
Cancer Discov. 2014 Feb;4(2):232-45
pubmed: 24356096
Clin Cancer Res. 2017 Sep 15;23(18):5561-5572
pubmed: 28606920
J Clin Oncol. 2013 Jul 10;31(20):2586-92
pubmed: 23733761
Acta Oncol. 2017 Apr;56(4):503-515
pubmed: 28358664
J Natl Cancer Inst. 2012 Jul 3;104(13):975-81
pubmed: 22761272
J Clin Oncol. 2019 Dec 20;37(36):3484-3492
pubmed: 31657982
Ann Oncol. 2020 Mar;31(3):387-394
pubmed: 32067680
NPJ Breast Cancer. 2018 May 4;4:10
pubmed: 29761158
N Engl J Med. 2020 Feb 27;382(9):810-821
pubmed: 32101663
Nat Commun. 2017 Oct 11;8(1):857
pubmed: 29021619
Sci Transl Med. 2019 Aug 21;11(506):
pubmed: 31434757
PLoS One. 2018 Jul 30;13(7):e0201116
pubmed: 30059519
J Clin Oncol. 2009 Aug 20;27(24):3908-15
pubmed: 19620495
Cancer Metastasis Rev. 2010 Jun;29(2):309-16
pubmed: 20405169
J Clin Oncol. 2020 Feb 10;38(5):423-433
pubmed: 31841354
BMC Med. 2015 Aug 13;13:188
pubmed: 26268938
JAMA Oncol. 2019 Jan 1;5(1):74-82
pubmed: 30242306
J Clin Oncol. 2008 Dec 1;26(34):5544-52
pubmed: 18955454
Ann Oncol. 2019 Mar 1;30(3):405-411
pubmed: 30475947
Exp Mol Med. 2019 Jan 7;51(1):1-13
pubmed: 30617282
Nat Rev Cancer. 2019 Mar;19(3):133-150
pubmed: 30755690
Cancer Lett. 2014 Oct 28;353(2):153-9
pubmed: 25130168
Ann Oncol. 2017 Mar 1;28(3):512-518
pubmed: 27993796
Mol Cancer Ther. 2012 Mar;11(3):720-9
pubmed: 22169769
Nat Genet. 2019 Feb;51(2):202-206
pubmed: 30643254
Mod Pathol. 2014 Sep;27(9):1212-22
pubmed: 24406864
N Engl J Med. 2018 Aug 23;379(8):753-763
pubmed: 30110579
Breast Cancer Res Treat. 2010 Jan;119(1):119-26
pubmed: 19669409
Nature. 2012 Apr 18;486(7403):346-52
pubmed: 22522925
Clin Cancer Res. 2013 Oct 1;19(19):5533-40
pubmed: 23948975
Lancet Oncol. 2017 Oct;18(10):1360-1372
pubmed: 28800861
Nat Med. 2017 Apr;23(4):517-525
pubmed: 28288110
J Clin Invest. 2011 Jul;121(7):2750-67
pubmed: 21633166
Cell. 2012 Apr 13;149(2):307-21
pubmed: 22500798