Sleep Modelling across Physiological Levels.
EEG
behaviour
circadian clocks
mathematical modelling
mean field
molecular mechanisms
multi-scale
neurons
sleep
systems biology
Journal
Clocks & sleep
ISSN: 2624-5175
Titre abrégé: Clocks Sleep
Pays: Switzerland
ID NLM: 101736579
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
20
12
2018
accepted:
25
02
2019
entrez:
22
10
2020
pubmed:
4
3
2019
medline:
4
3
2019
Statut:
epublish
Résumé
Sleep and circadian rhythms are regulated across multiple functional, spatial and temporal levels: from genes to networks of coupled neurons and glial cells, to large scale brain dynamics and behaviour. The dynamics at each of these levels are complex and the interaction between the levels is even more so, so research have mostly focused on interactions within the levels to understand the underlying mechanisms-the so-called reductionist approach. Mathematical models were developed to test theories of sleep regulation and guide new experiments at each of these levels and have become an integral part of the field. The advantage of modelling, however, is that it allows us to simulate and test the dynamics of complex biological systems and thus provides a tool to investigate the connections between the different levels and study the system as a whole. In this paper I review key models of sleep developed at different physiological levels and discuss the potential for an integrated systems biology approach for sleep regulation across these levels. I also highlight the necessity of building mechanistic connections between models of sleep and circadian rhythms across these levels.
Identifiants
pubmed: 33089162
doi: 10.3390/clockssleep1010015
pii: clockssleep-01-00015
pmc: PMC7509680
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
166-184Informations de copyright
© 2019 by the author.
Déclaration de conflit d'intérêts
Conflicts of InterestS.P. declares no conflict of interest. In the interest of full disclosure: S.P. is a theme leader at the Cooperative Research Centre for Alertness, Safety and Productivity and collaborates with Qantas on Passenger Wellbeing project. None of these activities are related to this review.
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