Biopsy-proven Henoch-Schönlein purpura nephritis: a single center experience.
Chronic kidney disease
HSPN
Immunoglobulin A vasculitis
Outcome
Pediatrics
Prognosis
Treatment
Journal
Pediatric nephrology (Berlin, Germany)
ISSN: 1432-198X
Titre abrégé: Pediatr Nephrol
Pays: Germany
ID NLM: 8708728
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
27
06
2020
accepted:
01
10
2020
revised:
23
08
2020
pubmed:
23
10
2020
medline:
15
2
2022
entrez:
22
10
2020
Statut:
ppublish
Résumé
Knowledge on normal progress and treatment of Henoch-Schönlein purpura nephritis (HSPN) is limited. This study reviews outcome, clinical, pathological, and therapeutic factors affecting the prognosis of HSPN patients. Forty-nine children with biopsy-confirmed HSPN diagnosed between September 2008 and 2018 were included. Demographics, clinical and laboratory data, treatment, and outcome were recorded at the time of biopsy, 3, 6, 12, and 24 months and at last visit. Clinical outcome was graded according to Meadow's criteria. The median age at time of biopsy was 10.1 years (IQR:5.7) and female/male ratio 24/25. At presentation, 40.8% of patients had nonnephrotic proteinuria, 18.4% nephrotic syndrome (NS), 4.1% nephritic syndrome (NephrS), and 36.7% NephrS+NS. There were 11 patients with an estimated glomerular filtration rate below 90 ml/min/1.73 m A large proportion of patients continued to show signs of CKD at last follow-up while only a small proportion developed stage 5 CKD.
Sections du résumé
BACKGROUND
Knowledge on normal progress and treatment of Henoch-Schönlein purpura nephritis (HSPN) is limited. This study reviews outcome, clinical, pathological, and therapeutic factors affecting the prognosis of HSPN patients.
METHODS
Forty-nine children with biopsy-confirmed HSPN diagnosed between September 2008 and 2018 were included. Demographics, clinical and laboratory data, treatment, and outcome were recorded at the time of biopsy, 3, 6, 12, and 24 months and at last visit. Clinical outcome was graded according to Meadow's criteria.
RESULTS
The median age at time of biopsy was 10.1 years (IQR:5.7) and female/male ratio 24/25. At presentation, 40.8% of patients had nonnephrotic proteinuria, 18.4% nephrotic syndrome (NS), 4.1% nephritic syndrome (NephrS), and 36.7% NephrS+NS. There were 11 patients with an estimated glomerular filtration rate below 90 ml/min/1.73 m
CONCLUSION
A large proportion of patients continued to show signs of CKD at last follow-up while only a small proportion developed stage 5 CKD.
Identifiants
pubmed: 33089378
doi: 10.1007/s00467-020-04809-8
pii: 10.1007/s00467-020-04809-8
pmc: PMC8009786
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1207-1215Commentaires et corrections
Type : CommentIn
Type : CommentIn
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