The impact of accurately timed mid-luteal endometrial injury in nulligravid women undergoing their first or second embryo transfer.
Endometrial scratch
Endometrium
Pregnancy
Unexplained infertility
Journal
Irish journal of medical science
ISSN: 1863-4362
Titre abrégé: Ir J Med Sci
Pays: Ireland
ID NLM: 7806864
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
20
01
2020
accepted:
17
10
2020
pubmed:
23
10
2020
medline:
5
10
2021
entrez:
22
10
2020
Statut:
ppublish
Résumé
Endometrial injury or 'scratch' preceding an assisted reproductive therapy (ART) cycle has recently been shown not to improve livebirth rates among women undergoing ART. The objective of this study was to compare pregnancy outcomes in nulliparous women who underwent an accurately timed mid-luteal scratch biopsy prior to ART with those who did not. This was a prospective cohort study. Women were recruited between October 2016 and February 2018 inclusive. Women who met the inclusion criteria and who did not undergo an endometrial scratch in the study period were used as a comparison group. Patients underwent a cycle of ART in the menstrual cycle following endometrial scratch. Ninety-eight women were eligible for participation in the study. There were no differences in rates of implantation (35.7% (n = 20/56) vs. 35.4% (n = 17/48); p = 1.00), clinical pregnancy (40.0% (n = 20/50) vs. 39.5% (n = 17/43); p = 1.00) or live birth (34.0% (n = 17/50) vs. 25.6% (n = 11/43); p = 0.50) per embryo transfer between those who underwent a scratch and those who did not. Endometrial scratch is a simple, inexpensive and low-risk procedure. However, in this relatively small cohort study, no differences in rates of implantation, clinical pregnancy or live birth in women with primary infertility were determined between those who underwent a scratch and those who did not.
Identifiants
pubmed: 33090349
doi: 10.1007/s11845-020-02414-0
pii: 10.1007/s11845-020-02414-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1071-1077Subventions
Organisme : UCD Wellcome Institutional Strategic Support Fund, which was financed jointly by University College Dublin and the SFI-HRB-Wellcome Biomedical Research Partnership
ID : 204833/Z/16/Z
Informations de copyright
© 2020. Royal Academy of Medicine in Ireland.
Références
Alpha Scientists in Reproductive, M., & Embryology, E. S. I. G. o (2011) The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod 26(6):1270–1283. https://doi.org/10.1093/humrep/der037
doi: 10.1093/humrep/der037
El-Toukhy T, Sunkara S, Khalaf Y (2012) Local endometrial injury and IVF outcome: a systematic review and meta-analysis. Reprod BioMed Online 25(4):345–354. https://doi.org/10.1016/j.rbmo.2012.06.012
doi: 10.1016/j.rbmo.2012.06.012
pubmed: 22885017
Gellersen B, Brosens IA, Brosens JJ (2007) Decidualization of the human endometrium: mechanisms, functions, and clinical perspectives. Semin Reprod Med 25(6):445–453. https://doi.org/10.1055/s-2007-991042
doi: 10.1055/s-2007-991042
pubmed: 17960529
Gnainsky Y, Granot I, Aldo P et al (2015) Biopsy-induced inflammatory conditions improve endometrial receptivity: the mechanism of action. Reproduction 149(1):75–85. https://doi.org/10.1530/REP-14-0395
doi: 10.1530/REP-14-0395
pubmed: 25349438
Grunfeld L, Walker B, Bergh PA et al (1991) High-resolution endovaginal ultrasonography of the endometrium: a noninvasive test for endometrial adequacy. Obstet Gynecol 78(2):200–4
Lensen S, Osavlyuk D, Armstrong S et al (2019) A randomized trial of endometrial scratching before in vitro fertilization. N Engl J Med 380(4):325–334. https://doi.org/10.1056/NEJMoa1808737
doi: 10.1056/NEJMoa1808737
pubmed: 30673547
Margalioth EJ, Ben-Chetrit A, Gal M, Eldar-Geva T (2006) Investigation and treatment of repeated implantation failure following IVF-ET. Hum Reprod 21(12):3036–3043. https://doi.org/10.1093/humrep/del305
doi: 10.1093/humrep/del305
pubmed: 16905766
Nastri CO, Lensen SF, Gibreel A et al (2015) Endometrial injury in women undergoing assisted reproductive techniques. Cochrane Database Syst Rev 3:CD009517. https://doi.org/10.1002/14651858.CD009517.pub3
doi: 10.1002/14651858.CD009517.pub3
Potdar N, Gelbaya T, Nardo LG (2012) Endometrial injury to overcome recurrent embryo implantation failure: a systematic review and meta-analysis. Reprod BioMed Online 25(6):561–571. https://doi.org/10.1016/j.rbmo.2012.08.005
doi: 10.1016/j.rbmo.2012.08.005
pubmed: 23063812
Shi Y, Sun Y, Hao C et al (2018) Transfer of fresh versus frozen embryos in ovulatory women. N Engl J Med 378(2):126–136. https://doi.org/10.1056/NEJMoa1705334
doi: 10.1056/NEJMoa1705334
pubmed: 29320646
Sigalos G, Triantafyllidou O, Vlahos NF (2016) Novel embryo selection techniques to increase embryo implantation in IVF attempts. Arch Gynecol Obstet 294(6):1117–1124. https://doi.org/10.1007/s00404-016-4196-5
doi: 10.1007/s00404-016-4196-5
Simon C, Martin JC, Pellicer A (2000) Paracrine regulators of implantation. Baillieres Best Pract Res Clin Obstet Gynaecol 14(5):815–826. https://doi.org/10.1053/beog.2000.0121
doi: 10.1053/beog.2000.0121
pubmed: 11023802
Tapia-Pizarro A, Figueroa P, Brito J et al (2014) Endometrial gene expression reveals compromised progesterone signaling in women refractory to embryo implantation. Reprod Biol Endocrinol 12:92. https://doi.org/10.1186/1477-7827-12-92
doi: 10.1186/1477-7827-12-92
pubmed: 25248672
pmcid: 4181418
van Hoogenhuijze NE, Kasius JC, Broekmans FJM et al (2019) Endometrial scratching prior to IVF; does it help and for whom? A systematic review and meta-analysis. Hum Reprod Open 2019(1):hoy025. https://doi.org/10.1093/hropen/hoy025
doi: 10.1093/hropen/hoy025
pubmed: 30895265
pmcid: 6396643
Van Sinderen M, Menkhorst E, Winship A et al (2013) Preimplantation human blastocyst-endometrial interactions: the role of inflammatory mediators. Am J Reprod Immunol 69(5):427–440. https://doi.org/10.1111/aji.12038
doi: 10.1111/aji.12038
pubmed: 23176081
Vitagliano A, Andrisani A, Alviggi C et al (2019) Endometrial scratching for infertile women undergoing a first embryo transfer: a systematic review and meta-analysis of published and unpublished data from randomized controlled trials. Fertil Steril 111(4):734–746 e732. https://doi.org/10.1016/j.fertnstert.2018.12.008
doi: 10.1016/j.fertnstert.2018.12.008
pubmed: 30683590
Zegers-Hochschild F, Adamson GD, Dyer S et al (2017) The international glossary on infertility and fertility care, 2017. Fertil Steril 108(3):393–406. https://doi.org/10.1016/j.fertnstert.2017.06.005
doi: 10.1016/j.fertnstert.2017.06.005
pubmed: 28760517
Zhou L, Li R, Wang R et al (2008) Local injury to the endometrium in controlled ovarian hyperstimulation cycles improves implantation rates. Fertil Steril 89(5):1166–1176. https://doi.org/10.1016/j.fertnstert.2007.05.064
doi: 10.1016/j.fertnstert.2007.05.064
pubmed: 17681303