Parallels between retinal and brain pathology and response to immunotherapy in old, late-stage Alzheimer's disease mouse models.

astrocytes reactivation glutamine synthetase myeloid cells neurodegenerative disease ocular proteins retina synaptic preservation vascular amyloidosis

Journal

Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839

Informations de publication

Date de publication:
14 Oct 2020
Historique:
received: 13 05 2020
revised: 14 08 2020
accepted: 09 09 2020
entrez: 22 10 2020
pubmed: 23 10 2020
medline: 23 10 2020
Statut: aheadofprint

Résumé

Despite growing evidence for the characteristic signs of Alzheimer's disease (AD) in the neurosensory retina, our understanding of retina-brain relationships, especially at advanced disease stages and in response to therapy, is lacking. In transgenic models of AD (APP

Identifiants

pubmed: 33090673
doi: 10.1111/acel.13246
pmc: PMC7681044
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e13246

Subventions

Organisme : The Saban Family Foundation
Organisme : The Maurice Marciano Family Foundation
Organisme : Tom Gordon Foundation
Organisme : Macquarie University
Organisme : NIA NIH HHS
ID : R01AG055865
Pays : United States
Organisme : Australian Government's National Collaborative Research Infrastructure Scheme
Organisme : NIA NIH HHS
ID : R01AG056478
Pays : United States
Organisme : National Health and Medical Research Council
Organisme : Petersen Foundation
Organisme : NIA NIH HHS
ID : R01 AG056478
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG055865
Pays : United States

Informations de copyright

© 2020 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

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Auteurs

Jonah Doustar (J)

Department of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.

Altan Rentsendorj (A)

Department of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.

Tania Torbati (T)

Department of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.
College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, USA.

Giovanna C Regis (GC)

Department of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.

Dieu-Trang Fuchs (DT)

Department of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.

Julia Sheyn (J)

Department of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.

Nazanin Mirzaei (N)

Department of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.

Stuart L Graham (SL)

Department of Clinical Medicine, Macquarie University, Sydney, NSW, Australia.
Save Sight Institute, Sydney University, Sydney, NSW, Australia.

Prediman K Shah (PK)

Oppenheimer Atherosclerosis Research Center, Cedars-Sinai Heart Institute, Los Angeles, CA, USA.

Mitra Mastali (M)

Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Cedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.

Jennifer E Van Eyk (JE)

Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Barbara Streisand Women's Heart Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Keith L Black (KL)

Department of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.

Vivek K Gupta (VK)

Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia.

Mehdi Mirzaei (M)

Department of Clinical Medicine, Macquarie University, Sydney, NSW, Australia.
Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia.
Australian Proteome Analysis Facility, Macquarie University, Sydney, NSW, Australia.

Yosef Koronyo (Y)

Department of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.

Maya Koronyo-Hamaoui (M)

Department of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Classifications MeSH