Drug therapies for chronic conditions and risk of Alzheimer's disease and related dementias: A scoping review.
Alzheimer's disease
dementia
drug therapies
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
03
04
2020
revised:
09
07
2020
accepted:
09
07
2020
pubmed:
23
10
2020
medline:
26
10
2021
entrez:
22
10
2020
Statut:
ppublish
Résumé
Most older Americans use drug therapies for chronic conditions. Several are associated with risk of Alzheimer's disease and related dementias (ADRD). A scoping review was used to identify drug classes associated with increasing or decreasing ADRD risk. We analyzed size, type, and findings of the evidence. We identified 29 drug classes across 11 therapeutic areas, and 404 human studies. Most common were studies on drugs for hypertension (93) or hyperlipidemia (81). Fewer than five studies were identified for several anti-diabetic and anti-inflammatory drugs. Evidence was observational only for beta blockers, proton pump inhibitors, benzodiazepines, and disease-modifying anti-rheumatic drugs. For 13 drug classes, 50% or more of the studies reported consistent direction of effect on risk of ADRD. Future research targeting drug classes with limited/non-robust evidence, examining sex, racial heterogeneity, and separating classes by molecule, will facilitate understanding of associated risk, and inform clinical and policy efforts to alleviate the growing impact of ADRD.
Identifiants
pubmed: 33090701
doi: 10.1002/alz.12175
pmc: PMC8112164
mid: NIHMS1663238
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
41-48Subventions
Organisme : NIA NIH HHS
ID : R37 AG053589
Pays : United States
Organisme : NIH HHS
ID : R01AG055401
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG043073
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG026572
Pays : United States
Organisme : NIH HHS
ID : P01AG026572
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG057931
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG055401
Pays : United States
Informations de copyright
© 2020 the Alzheimer's Association.
Références
Indian J Psychiatry. 2009 Jan;51(1):12-25
pubmed: 19742190
J Gerontol B Psychol Sci Soc Sci. 2018 Apr 16;73(suppl_1):S38-S47
pubmed: 29669100
Alzheimers Dement. 2017 Oct;13(10):1077-1080
pubmed: 28935202
Alzheimers Dement. 2010 Mar;6(2):98-103
pubmed: 20298969
Curr Med Chem. 2018;25(18):2166-2174
pubmed: 29376492
Drugs Aging. 2012 May 1;29(5):335-42
pubmed: 22500970
Endocrinol Metab Clin North Am. 2013 Sep;42(3):489-501
pubmed: 24011882
Alzheimers Dement. 2018 Mar;14(3):263-270
pubmed: 29055814
BMJ. 2010 May 20;340:c2197
pubmed: 20488911
Expert Rev Cardiovasc Ther. 2017 Dec;15(12):897-903
pubmed: 29179605
BMJ. 2016 Feb 02;352:i90
pubmed: 26837813
Int J Clin Pract. 2008 Nov;62(11):1792-800
pubmed: 18699842
Drug Saf. 2015 Oct;38(10):909-19
pubmed: 26123874
Neurobiol Aging. 2011 Sep;32(9):1626-33
pubmed: 19923038
Nat Rev Neurol. 2018 Nov;14(11):653-666
pubmed: 30291317
Expert Opin Investig Drugs. 2009 Aug;18(8):1147-68
pubmed: 19589092
Alzheimers Dement. 2012 Sep;8(5):437-44
pubmed: 22521970
Transl Psychiatry. 2013 Dec 03;3:e332
pubmed: 24301650
Neurology. 2013 Sep 3;81(10):888-95
pubmed: 23911753
PLoS One. 2018 Nov 1;13(11):e0206705
pubmed: 30383807
Alzheimers Dement (N Y). 2018 May 03;4:195-214
pubmed: 29955663
Geriatr Gerontol Int. 2013 Jan;13(1):90-7
pubmed: 22672107
Int J Neurosci. 2016;126(4):299-307
pubmed: 26001206
PLoS One. 2012;7(11):e49113
pubmed: 23145088
Drug Saf. 2018 Jun;41(6):615-624
pubmed: 29397553
BMJ. 2015 Jun 16;350:h3029
pubmed: 26079686
Diabetes Care. 2019 May;42(5):972-979
pubmed: 30833374
BMC Med Res Methodol. 2018 Nov 19;18(1):143
pubmed: 30453902
PLoS One. 2020 Mar 4;15(3):e0229541
pubmed: 32130251
Curr Cardiol Rep. 2015 Feb;17(2):4
pubmed: 25618304
J Am Geriatr Soc. 2019 Apr;67(4):674-694
pubmed: 30693946
JAMA. 2020 Jan 28;323(4):297-299
pubmed: 31913419
J Am Geriatr Soc. 2009 Jan;57(1):177-9
pubmed: 19170800
Alzheimers Dement. 2019 Nov;15(11):1402-1411
pubmed: 31494079
Lancet. 2017 Dec 16;390(10113):2673-2734
pubmed: 28735855
Alzheimers Res Ther. 2015 Dec 27;7:79
pubmed: 26714488
BMJ. 2014 Sep 09;349:g5205
pubmed: 25208536
J Intern Med. 2015 Mar;277(3):343-352
pubmed: 24766342
Age Ageing. 2016 Jul;45(4):448-56
pubmed: 27055878
Am J Epidemiol. 2019 Jul 1;188(7):1228-1236
pubmed: 31111865
Eur J Pharmacol. 2010 Jan 10;626(1):64-71
pubmed: 19837057
PLoS One. 2017 Feb 15;12(2):e0171006
pubmed: 28199356
Ann Intern Med. 2018 Jan 2;168(1):30-38
pubmed: 29255839
Alzheimers Res Ther. 2017 Feb 17;9(1):10
pubmed: 28212683
Neurobiol Aging. 1992 Mar-Apr;13(2):197-8; discussion 199
pubmed: 1522938
JAMA Neurol. 2017 Feb 1;74(2):225-232
pubmed: 27942728
J Gerontol A Biol Sci Med Sci. 2014 Oct;69(10):1299-305
pubmed: 24899525